Strength training reverses ovariectomy-induced bone loss and improve metabolic parameters in female Wistar rats

Publication date: Available online 18 October 2018Source: Life SciencesAuthor(s): Rodrigo Mello Gomes, Marcos Divino Ferreira Junior, Flávio Andrade Francisco, Veridiana Mota Moreira, Douglas Lopes de Almeida, Lucas Paulo Jacinto Saavedra, Júlio Cezar de Oliveira, Claudinéia Conationi da Silva Franco, Gustavo Rodrigues Pedrino, Paulo Cezar de Freitas Mathias, Maria Raquel Marçal Natali, Melquisedeque Juliani Dias, Isaías Júlio de Morais, Solange Marta Franzói de MoraesAbstractMenopause induces osteoporosis, sarcopenia, insulin resistance, and dyslipidemia. Ovariectomized (OVX) rat is an animal model, which mimetics postmenopausal conditions. The present study aimed to test the effects of strength training protocol on bone mineral density and metabolic parameters in OVX rats. Female Wistar rats were randomly separated in four groups: non-ovariectomized rats (Sham); ovariectomized rats (OVX); OVX treated with 17β-estradiol (HR); and OVX trained group (TR). At 70-days-old OVX groups were submitted to a bilateral ovariectomy. Hormonal replacement and strength training were performed three times per week, for 60 days. 17β-estradiol was administered by intramuscular injection (50 μg/kg of BW) and strength training protocol was composed by four series of 12 repetitions with 65–75% of 1RM. As expected, OVX impaired glucose homeostasis, promoted weight and adiposity gain, dyslipidemia, sarcopenia and osteoporosis, but hormonal replacement and strength training improved...
Source: Life Sciences - Category: Biology Source Type: research