A Probable Topiramate-Induced Limbs Paraesthesia and Rigid Fingers Flexion.

We report on a girl affected by epileptic seizures treated with levetiracetam for five years. Due to worsening of the seizures, the dosage of this drug was increased and afterwards lowdosage topiramate was initiated. After 12 days from the introduction of topiramate, the girl began to present neurologic signs including limbs rigidity, pain, incoordination and flexed fingers. Gradual withdrawn of the topiramate resulted in progressive resolution of the symptomatology. This clinical episode could represent a probable topiramate-related side effect (Naranjo score 5), never reported before in this form. PMID: 29437013 [PubMed - indexed for MEDLINE]
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Drug Saf Source Type: research