History of the repair of oxidative DNA damage

Date: Tuesday, 03 19, 2019; Speaker: Dr. Arthur Grollman and Dr. Bruce Demple, History of the repair of oxidative DNA damage, SUNY; Porter (Building 35A); 640; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events

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Publication date: Available online 23 April 2019Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Dae-Hee Lee, Darryl D. D’Lima, Sang Hak LeeAbstractPurposeSome reports have noted favorable long-term clinical results with milder postoperative arthritic changes after total meniscectomy in symptomatic patients with torn discoid lateral meniscus (DLM). This meta-analysis was conducted to compare the clinical and radiographic results between partial and total meniscectomy in patients with symptomatic DLM.MethodsStudies were included in the meta-analysis if (1) they analysed patients who underwent ar...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
The objective of this study was to evaluate the change over time in the number of alternative surgical procedures (meniscectomy and meniscus repair) and regional variation in France using data from the French agency for information on hospital care (ATIH).HypothesisWe hypothesized that the number of meniscectomy procedures will decrease, and the number of repair procedures will increase over time at various healthcare facilities.Patients and methodsBetween 2005 and 2017, the number of hospitalizations in the Medicine-Surgery-Obstetrics wards for meniscectomy (NFFC003 and NFCC004) or meniscus repair (NFEC001 and NFEC002) wa...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
An aortoesophageal fistula, an abnormal anatomical communication between the aorta and the esophagus, is a rare cause of upper gastrointestinal bleeding. The mortality rate of patients with this condition is very high. A 77-year-old man, who had undergone endovascular aortic repair for a ruptured abdominal aortic aneurysm, developed melena. An upper gastrointestinal endoscopy was performed. This detected an esophageal ulcer, which had the potential to develop into an aortoesophageal fistula. Therefore, thoracic endovascular aortic repair was performed on the following day. Thereafter, the course was uneventful. We encounte...
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 24 April 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Xiangwei Li, Xiaohua Liu, Shilei Ni, Yanan Liu, Hongchen Sun, Quan LinSummaryPurposeTo evaluate the effects of simvastatin in a new injectable microsphere hydrogel system on bone healing process of tooth sockets.Materials and MethodsSimvastatin was loaded in poly(lactic-co-glycolic acid) (PLGA) microspheres using an emulsion process, and the drug-loaded PLGA microspheres were further entrapped in a gelatin hydrogel to form an injectable microsphere-hydrogel system. Simvastatin-free hydrogel and blank microspheres hydro...
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
ECZEMA is a condition that causes a person ’s skin to become sore, itchy, dry and cracked. While experts recommend emollients and steroid creams, these don’t always work for everyone. An alternative, natural remedy, which cold prove effective, contains the ingredient oats.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: In this series of patients, the PMVT graft demonstrated improved wound closure, increased local perfusion and vascular maturity, and improved tissue quality. This graft is a promising advanced tissue therapy for nonhealing DFUs and other complex wounds. It is now the subject of a randomized controlled trial. PMID: 31008717 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
Publication date: 23 April 2019Source: Cell Reports, Volume 27, Issue 4Author(s): Carlo Sala Frigerio, Leen Wolfs, Nicola Fattorelli, Nicola Thrupp, Iryna Voytyuk, Inga Schmidt, Renzo Mancuso, Wei-Ting Chen, Maya E. Woodbury, Gyan Srivastava, Thomas Möller, Eloise Hudry, Sudeshna Das, Takaomi Saido, Eric Karran, Bradley Hyman, V. Hugh Perry, Mark Fiers, Bart De StrooperSummaryGene expression profiles of more than 10,000 individual microglial cells isolated from cortex and hippocampus of male and female AppNL-G-F mice over time demonstrate that progressive amyloid-β accumulation accelerates two main activated micr...
Source: Cell Reports - Category: Cytology Source Type: research
Authors: Dong X, Liu J, Xu Y, Cao H Abstract Liver macrophages make up the largest proportion of tissue macrophages in the host and consist of two dissimilar groups: Kupffer cells (KCs) and monocyte-derived macrophages (MoMø). As the liver is injured, KCs sense the injury and initiate inflammatory cascades mediated by the release of inflammatory cytokines and chemokines. Subsequently, inflammatory monocytes accumulate in the liver via chemokine-chemokine receptor interactions, resulting in massive inflammatory MoMø infiltration. When live r injury ceases, restorative macrophages, derived from recruite...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Congenitally corrected transposition of the great arteries (ccTGA) is a lesion that rarely occurs in isolation. The presenting physiology of ccTGA is predominantly secondary to the concurrent cardiac lesions; however, as the child ages, unrepaired ccTGA results in progressive failure of the morphologic right ventricle under the strain of maintaining a systemic pressure. Repair of ccTGA was initially focused on rectification of the underlying physiologic aberrations, but in recent years, the focus of repair has shifted toward anatomic correction to avoid failure of the morphologic right ventricle.
Source: Seminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery Annual - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Aortic coarctation/arch hypoplasia is a relatively common congenital heart disease that leads to severe cardiovascular complications if left untreated. During the modern era, the mortality of the primary surgical repair is very low but the long-term issues, such as recurrent coarctation/arch reobstruction and hypertension, are still significant challenges. The former is related to the surgical repair performed particularly in the management of the smallish distal aortic arch, and for the latter, despite the “successful” repair of the aortic coarctation, the intrinsic vascular anomaly remains a significant long-term morbidity.
Source: Seminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery Annual - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
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