History of the repair of oxidative DNA damage

Date: Tuesday, 03 19, 2019; Speaker: Dr. Arthur Grollman and Dr. Bruce Demple, History of the repair of oxidative DNA damage, SUNY; Porter (Building 35A); 640; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events

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Publication date: Available online 12 December 2018Source: Social Science &MedicineAuthor(s): Amelia M. Jamison, Sandra Crouse Quinn, Vicki S. FreimuthAbstractVaccine confidence depends on trust in vaccines as products and trust in the system that produces them. In the US, this system consists of a complex network connecting pharmaceutical companies, government agencies, and the healthcare system. We explore narratives from White and African American adults describing their trust in these institutions, with a focus on influenza vaccine. Our data were collected between 2012 and 2014 as part of a mixed-methods investigat...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
The nervous system in general is not particularly regenerative, but peripheral nervous system tissue is more capable of repair than central nervous system tissue. Focusing on neurons that link these two parts of the nervous system, researchers here report on mechanisms involved in repair of nervous system cells, and propose that it might be possible to make central nervous system cells act more like peripheral nervous system cells in this regard. Whether or not this can be achieved safely is another question, however; this is very early stage work, too early to answer many questions about safety and plausibility. ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
MEK inhibitor enhanced the antitumor effect of oxaliplatin and 5‑fluorouracil in MEK1 Q56P‑mutant colorectal cancer cells. Mol Med Rep. 2018 Dec 07;: Authors: Jing C, Li H, Du Y, Cao H, Liu S, Wang Z, Ma R, Feng J, Wu J Abstract Mitogen‑activated protein kinase kinase (MEK) small molecule inhibitors have been investigated in preclinical or clinical trials for the treatment of cancer. In the present study the genetic test results of 120 patients with colorectal cancer (CRC) were screened and the mutation rate of MEK1 was identified to be 1.67%. MEK inhibition by U0126 significantly decreased ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Upregulated IGF‑1 in the lungs of asthmatic mice originates from alveolar macrophages. Mol Med Rep. 2018 Dec 05;: Authors: He J, Mu M, Wang H, Ma H, Tang X, Fang Q, Guo S, Song C Abstract Asthma is characterized by inflammation and remodeling of the airways. Insulin‑like growth factor-1 (IGF‑1) serves an important role in the repair of lung tissue injury and airway remodeling by elevating collagen and elastin content, increasing the thickness of smooth muscle and promoting the proliferation of lung epithelial and interstitial cells, as well as fibroblasts; however, the content of IGF‑1 and...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
AbstractCardiovascular disease (CVD) is still a factor of mortality in the whole world. Through canonical and noncanonical pathways and with different receptors, the Wnt/ β-catenin signaling pathway plays an essential role in response to heart injuries. Wnt regulates the mobilization and proliferation of cells in endothelium and epicardium in an infarcted heart. Therefore, with its profibrotic effects as well as its antagonism with other proteins, Wnt/β-catenin sig naling pathway leads to beneficial effects on fibrosis and cardiac remodeling in myocardium. In addition, Wnt increases the proliferation and differen...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
AbstractPurposeTo investigate, whether cartilage repair surgery for focal osteochondral defects at the knee results in less degenerative changes over 6  years in a MR imaging follow-up than morphologically initially identical defects in non-operated control subjects from the osteoarthritis initiative (OAI).MethodsA total of 32 individuals received baseline and follow-up MRI. Inn = 16 patients with cartilage repair [osteochondral autograft transfer system (OATS),n = 12; spongiosa-augmented matrix-associated autologous chondrocyte implantation (MACI),n = 4] MRI was performed pre...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Publication date: December 2018Source: The Journal of Prosthetic Dentistry, Volume 120, Issue 6Author(s): Carine Matthys, Stijn Vervaeke, Wolfgang Jacquet, Hugo De BruynAbstractStatement of problemThe influence of the mandibular resorption profile on clinical outcome after converting a conventional complete denture into a Locator-retained implant overdenture is unknown.PurposeThe purpose of this prospective study was to assess the oral health-related quality of life (OHRQoL) and prosthetic maintenance of mandibular overdentures on 2 Locator abutments in relation to the resorption degree of the edentulous mandible.Material ...
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
Cryopreservation via a cryonics provider, such as Alcor or the Cryonics Institute in the US, is presently the only option available to the billions who will age to death prior to the advent of a comprehensive package of rejuvenation therapies. Sadly, it is not yet a well-developed industry, operating at scale. The technology exists to vitrify people immediately following clinical death, preserving the fine structure of brain tissue if the vitrification process is of sufficiently high quality, but very few people choose to take advantage of this opportunity. Every year, tens of millions go to oblivion rather than chose the ...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
In this study, isobaric tags for relative and absolute quantitation (iTRAQ) based proteomic profiling was pursued to investigate the responses of zygotes of the Pacific oyster Crassostrea gigas to low salinity. A total of 2235 proteins were identified and 87 proteins were considered differentially expressed, of which 14 were up-regulated and 69 were down-regulated. Numerous functional proteins including ADP ribosylation factor 2, DNA repair protein Rad50, splicing factor 3B, tubulin-specific Chaperone D were significantly changed in abundance, and were involved in various biology processes including energy generation, vesi...
Source: Comparative Biochemistry and Physiology Part D: Genomics and Proteomics - Category: Genetics & Stem Cells Source Type: research
ConclusionThis case demonstrates that robotic repair of a Morgagni hernia, even with massive hernia content, is feasible in adolescents. However, whether robotic surgery in general, and for Morgagni hernia in particular, is superior to laparoscopy in children, remains to be proven.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
More News: American Health | Gastroschisis Repair