ASAP Microfluidic-Based Genosensor To Detect Human Papillomavirus (HPV16) for Head and Neck Cancer

ACS Applied Materials&InterfacesDOI: 10.1021/acsami.8b14632
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research

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In this study, we extended this observation by performing a computational analysis of 33 other cancer types as well as human cancer cell lines, and identified additionalPD-L1 isoforms with an exon 4 enrichment expressed in 20 cancers and human cancer cell lines. We demonstrate that cancer cell lines with high expression levels of exon 4-enrichedPD-L1 generate a secreted form of PD-L1. Further biochemical studies of exon 4-enriched PD-L1 demonstrated that this form is secreted and maintains the capacity to bind PD-1 as well as to serve as a negative regulator on T cell function, as measured by inhibition of IL-2 and IFNg se...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
Lanwei Guo, Funa Yang, Yulin Yin, Shuzheng Liu, Peng Li, Xiaojun Zhang, Defeng Chen, Yang Liu, Jian Wang, Kai Wang, Yiming Zhu, Qing Lv, Xiaoyu Wang, Xibin Sun
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Rui Medeiros High-risk human papillomavirus (HPV)-driven cancers represent a major health concern worldwide. Despite the constant effort to develop and promote vaccination against HPVs, there is still a high percentage of non-vaccinated population. Furthermore, secondary prevention programs are not ubiquitous worldwide and not widely followed. Metastatic disease is the cause of the great majority of cancer-associated deaths, making it essential to determine its underlying mechanisms and to identify actionable anti-metastatic targets. Within certain types of cancer (e.g., head and neck), HPV-positive tumors show diffe...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Abstract Standardized, synoptic pathologic reporting for tumors greatly improves communication among clinicians, patients, and researchers, supporting prognostication and comparison about patient outcomes across institutions and countries. The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Within the head and neck region, lymph node excisions and neck dissections are frequently performed as part of the management of head and neck cancers arising from the mucosal sites (sinonasal tr...
Source: Archives of Pathology and Laboratory Medicine - Category: Laboratory Medicine Authors: Tags: Arch Pathol Lab Med Source Type: research
rmeer Tumor cell metabolism differs from that of normal cells, conferring tumors with metabolic advantages but affording opportunities for therapeutic intervention. Accordingly, metabolism-targeting therapies have shown promise. However, drugs targeting singular metabolic pathways display limited efficacy, in part due to the tumor’s ability to compensate by using other metabolic pathways to meet energy and growth demands. Thus, it is critical to identify novel combinations of metabolism-targeting drugs to improve therapeutic efficacy in the face of compensatory cellular response mechanisms. Our lab has previo...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Objectives/HypothesisAnalyze the characteristics of second primary lung malignancies (SPLMs) following an index head and neck squamous cell carcinoma (HNSCC).Study DesignRetrospective cohort study.MethodsThe Surveillance, Epidemiology and End Results database was queried for all cases of HNSCC between 1973 and 2014 (N  = 101,856). This population was compared to a standard population to assess relative risk for lung cancer, calculated as the standardized incidence ratio (SIR). Patients who developed SPLMs were extracted (N = 8,116) and compared to all other cases of lung cancer (N =&thins...
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Head and Neck Source Type: research
This article highlights the evidence-based data to support systemic treatment options for patients with head and neck squamous cell carcinoma (HNSCC). The discovery of the human papillomavirus epidemic in HNSCC and its favorable prognosis has led to a major focus of research. Patients are stratified into clinical or pathologic risk categories and enrolled in trials comparing standard treatment paradigms with deintensification, in low-risk disease, or to intensification, in intermediate-risk or high-risk disease. Immunotherapy has proven beneficial in second-line palliative therapy and is under investigation in first-line p...
Source: The Surgical Clinics of North America - Category: Surgery Authors: Tags: Oral Maxillofac Surg Clin North Am Source Type: research
Conclusions: Tumor regression can occur following treatment of an epithelial cancer with gene-engineered T cells. These findings support continued study of E7 T cells and possibly other types of gene-engineered T cells in epithelial cancers.DisclosuresAdhikary: Kite Pharma: Employment. Schweitzer: Kite Pharma: Employment. Astrow: Kite Pharma: Employment. Hinrichs: Kite Pharma: Research Funding; NIH: Patents &Royalties: NIH patents related to cell therapy.
Source: Blood - Category: Hematology Authors: Tags: 801. Gene Therapy and Transfer: Clinical Trials for Hemophilia and Using CAR T Cells Source Type: research
Publication date: Available online 15 November 2018Source: The LancetAuthor(s): Hisham Mehanna, Max Robinson, Andrew Hartley, Anthony Kong, Bernadette Foran, Tessa Fulton-Lieuw, Matthew Dalby, Pankaj Mistry, Mehmet Sen, Lorcan O'Toole, Hoda Al Booz, Karen Dyker, Rafael Moleron, Stephen Whitaker, Sinead Brennan, Audrey Cook, Matthew Griffin, Eleanor Aynsley, Martin Rolles, Emma De WintonSummaryBackgroundThe incidence of human papillomavirus (HPV)-positive oropharyngeal cancer, a disease affecting younger patients, is rapidly increasing. Cetuximab, an epidermal growth factor receptor inhibitor, has been proposed for treatmen...
Source: The Lancet - Category: General Medicine Source Type: research
This article highlights the evidence-based data to support systemic treatment options for patients with head and neck squamous cell carcinoma (HNSCC). The discovery of the human papillomavirus epidemic in HNSCC and its favorable prognosis has led to a major focus of research. Patients are stratified into clinical or pathologic risk categories and enrolled in trials comparing standard treatment paradigms with deintensification, in low-risk disease, or to intensification, in intermediate-risk or high-risk disease. Immunotherapy has proven beneficial in second-line palliative therapy and is under investigation in first-line p...
Source: Oral and Maxillofacial Surgery Clinics - Category: ENT & OMF Authors: Source Type: research
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