Molecules, Vol. 23, Pages 2697: Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea
Molecules, Vol. 23, Pages 2697: Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea
Molecules doi: 10.3390/molecules23102697
Authors:
Birthe Sandargo
Benjarong Thongbai
Dimas Praditya
Eike Steinmann
Marc Stadler
Frank Surup
4-Hydroxypleurogrisein, a congener of the anticancer-lead compound pleurotin, as well as six further derivatives were isolated from the basidiomycete Hohenbuehelia grisea, strain MFLUCC 12-0451. The structures were elucidated utilizing high resolution electron spray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectral data and evaluated for their biological activities; for leucopleurotin, we provide Xray data. While most congeners showed moderate antimicrobial and cytotoxic activity, 4-hydroxypleurogrisein emerged as an inhibitor of hepatitis C virus infectivity in mammalian liver cells.
Source: Molecules - Category: Chemistry Authors: Birthe Sandargo Benjarong Thongbai Dimas Praditya Eike Steinmann Marc Stadler Frank Surup Tags: Article Source Type: research