Microdevice Placement for Precision-Based Lung Cancer Therapy for Patients Undergoing Surgical Resection

Many lung cancer patients who undergo surgical resection ultimately require adjuvant therapy, yet current chemosensitivity models inadequately predict therapeutic response. We propose using a microdevice to test lung tumor responsiveness to simultaneous microdoses of 20 to 30 antineoplastic agents released directly into a tumor prior to operative resection. The 750 μm device is inserted into a tumor prior to surgery and remains in vivo until retrieval during surgical resection. Analysis of the cellular architecture surrounding the device using clinically relevant biomarkers and multiparameter immunohistochemistry yields an individualized characterization of t he tumor response to each drug.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Scientific poster presentations Source Type: research