Inhibition of IL-10 Augments Mesothelin Chimeric Antigen Receptor T Cell Activity in Epithelial Ovarian Cancer

Epithelial ovarian cancer (EOC) cells are known to shield themselves from immunosurveillance by secreting immune inhibitory cytokines such as IL-10. Using mesothelin, a differentiating antigen that is overexpressed in EOC, we assessed the effect of the tumor microenvironment on chimeric antigen receptor (CAR) T cell-based immunotherapy and its reversal via IL-10 depletion.

Source: Journal of the American College of Surgeons - October 1, 2018 Category: Surgery Authors: Ramesh B. Batchu, Oksana V. Gruzdyn, Ebrahem M. Mahmud, Sagar Rohondia, Santosh K. Manmari, Suman P. Tavva, Udaya P. Sri, Gamal Mostafa, Donald W. Weaver, Scott A. Gruber Tags: Scientific poster presentations Source Type: research