Cerebrovascular disorders associated with genetic lesions.

Cerebrovascular disorders associated with genetic lesions.
Cell Mol Life Sci. 2018 Oct 16;:
Authors: Karschnia P, Nishimura S, Louvi A
Abstract
Cerebrovascular disorders are underlain by perturbations in cerebral blood flow and abnormalities in blood vessel structure. Here, we provide an overview of the current knowledge of select cerebrovascular disorders that are associated with genetic lesions and connect genomic findings with analyses aiming to elucidate the cellular and molecular mechanisms of disease pathogenesis. We argue that a mechanistic understanding of genetic (familial) forms of cerebrovascular disease is a prerequisite for the development of rational therapeutic approaches, and has wider implications for treatment of sporadic (non-familial) forms, which are usually more common.
PMID: 30327838 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - October 16, 2018 Category: Cytology Authors: Karschnia P, Nishimura S, Louvi A Tags: Cell Mol Life Sci Source Type: research