Miami biotech receives $3.8M grant

A Miami-based biopharmaceutical company researching antidotes for aging-related diseases has received a $3.8 million grant. Longeveron LLC, founded in 2014, will use the new funding from the National Institutes of Health (NIH) Small Business Innovation Research (SBIR) grant toward developing stem cell therapies for aging frailty, a physiological decline from aging that the company says heightens vulnerability to advers e and serious health conditions in older people. The syndrome affects 10 percent…
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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Publication date: Available online 18 March 2019Source: Stem Cell ResearchAuthor(s): Aditya S. Pawar, Alfonso Eirin, James D. Krier, John R. Woollard, Xiang-Yang Zhu, Amir Lerman, Andre J. van Wijnen, Lilach O. LermanAbstractIntroductionMesenchymal stem cells (MSCs) possess endogenous reparative properties and may serve as an exogenous therapeutic intervention in patients with chronic kidney disease. Cardiovascular risk factors clustering in the metabolic syndrome (MetS) might adversely affect cellular properties. To test the hypothesis that Mets interferes with MSC characteristics, we performed comprehensive comparison of...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
We present evidence from previous works on the important phenotypic changes of various neuronal types in these neurological diseases. We also summarize efforts on conducting low- and high-throughput screening experiments with hiPSCs toward developing potential therapeutics for treatment of neurodegenerative diseases. Lastly, we discuss the limitations of hiPSCs culture system in studying neurodegenerative diseases and alternative strategies to overcome these drawbacks.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
In conclusion, EPO attenuates high glucose-induced oxidative stress, inhibitory effect of proliferation and inhibition of osteogenic differentiation in periodontal ligament stem cell (PDLSCs).
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 16 March 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Tommy Nordström, Leif C. Andersson, Karl E.O. ÅkermanAbstractA stroke causes a hypoxic brain microenvironment that alters neural cell metabolism resulting in cell membrane hyperpolarization and intracellular acidosis. We studied how intracellular pH (pHi) is regulated in differentiated mouse neural progenitor cells during hyperpolarizing conditions, induced by prompt reduction of the extracellular K+ concentration. We found that the radial glia-like population in differentiating embryonic neural p...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Primary mesenchymal stem cells (MSCs) are fraught with aging-related shortfalls. Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been shown to be a useful clinically relevant source of MSC...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
The manufacture of mesenchymal stem/stromal cells (MSCs) for clinical use needs to be cost effective, safe and scaled up. Current methods of expansion on tissue culture plastic are labour-intensive and involve...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Mesenchymal stem cells (MSCs) are increasingly being applied as a therapy for liver fibrosis. Exosomes possess similar functions to their parent cells; however, they are safe and effective cell-free reagents w...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
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Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Review Source Type: research
AbstractPurpose of ReviewCellular therapy started in the early twentieth century with the development of blood transfusion and later bone marrow transplantation. This review describes the historical origins and major milestones in the field of cellular therapy. We discuss ethical concerns associated with certain cell sources and how they influenced therapy strategies. A focus of this article is on the use of stem cells to understand regenerative repair after kidney injury. In addition, we give an overview over past and current kidney-related cellular therapy trials.Recent FindingsThe number of kidney-related cellular thera...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
Stem Cells and Development, Ahead of Print.
Source: Stem Cells and Development - Category: Stem Cells Authors: Source Type: research
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