Highly biocompatible BSA-MnO2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy

Publication date: November 2018Source: Chinese Chemical Letters, Volume 29, Issue 11Author(s): Yuzhen Wang, Yujun Song, Guixian Zhu, Dechen Zhang, Xuewu LiuAbstractMore recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared (NIR) photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin (BSA)-reduced and stabilized MnO2 nanoparticles (BSA-MnO2 NPs) with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent.Graphical abstractIn this work, we reported a facile, one-pot method to synthesis of bovine serum albumin (BSA)-reduced and stabilized MnO2 nanoparticles (BSA-MnO2 NPs) with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior near infrared (NIR) photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research