NFAT5 regulates renal gene expression in response to Angiotensin II through Annexin-A2-mediated post-transcriptional regulation in hypertensive rats.

In conclusion, we show that ANGII increases Annexin-A2 nucleic acid binding activity that correlates with elevated protein levels of the NFAT5 transcription factor. NFAT signalling appears to be a major contributor to renal gene regulation in high-renin states.
PMID: 30332317 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - October 17, 2018 Category: Urology & Nephrology Authors: Fähling M, Paliege A, Jönsson S, Becirovic-Agic M, Melville JM, Skogstrand T, Hultström M Tags: Am J Physiol Renal Physiol Source Type: research