Quantifying the angiogenesis of C6 glioma in rats based on CT quantitative parameters.
Quantifying the angiogenesis of C6 glioma in rats based on CT quantitative parameters. Acta Radiol. 2018 Oct 15;:284185118808073 Authors: Huang X, Liang X, Zhang Q, Wang D, Liu J, Zhang L, Zhou J Abstract Background Glioma is the most common neoplasm that is neuroepithelial in nature. However, Spectral computed tomography (CT) has rarely been reported to detect angiogenesis in tumors. Purpose To investigate the value of multi-parameter spectral CT for the detection of angiogenesis in C6 glioma in rats. Material and Methods Fifteen male Wistar rats were seeded with C6 glioma cells in the right basal ganglia and spectral CT-enhanced scanning was performed at days 7, 10, and 14 after the C6 glioma cells were seeded. The spectral CT parameters were measured in three areas: the solid tumor; the peritumoral area; and the contralateral mirror area. After different periods of scanning, the rats' brain tissue was stained with HE and CD105 immunohistochemical staining. Different periods of spectral CT quantitative parameters and pathological images were analyzed. Results The spectral CT parameter and CD105 among the solid tumor, peritumoral area, and contralateral mirror area were significantly different: monochromatic CT value (211.30 ± 34.67 HU, 119.16 ± 13.31 HU, and 55.59 ± 7.87 HU, P
Conclusion : Stereotactic biopsy is a less invasive procedure for obtaining samples of brain tumors for diagnosis. The bleeding of the tissue-resection cavity that includes asymptomatic hemorrhage occurs at a constant rate. It is important to reduce the symptomatic bleeding associated with stereotactic biopsy. J. Med. Invest. 66 : 314-318, August, 2019. PMID: 31656296 [PubMed - in process]
Abstract13N-Ammonia (13N-NH3) is widely used positron emission tomography/computed tomography (PET/CT) radiotracer for the measurement of myocardial blood perfusion; the possible role of13N-NH3 PET or PET/CT in oncological disease is not yet clear. Aim of this review is to evaluate the diagnostic performances of13N-NH3 PET in this field. A comprehensive computer literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted including articles up to June 2019. Eighteen articles were finally included in the review. From the analyses of the selected studies, the following main findings could be drawn: (1)...
Conclusion We ascribe the incorrect diagnosis to insufficient understanding on imaging manifestations of brain neoplasm as well as clinical features of parasitosis. Thus, we review the MRI, FDG-PET-CT, MRS and DTI data of this case according to the timeline, refer to relevant studies, and point out the pitfalls. With a long course of slowly progressing, this was a rare case of secondary glioblastoma with the absence of isocitrate dehydrogenase 1 (IDH1) gene mutation.
ConclusionThis case joins less than 20 other reported cases of oligodendroglioma bone marrow metastasis, and is one of only a handful of cases of diffuse bone metastases beyond the axial skeleton. To the best of our knowledge, the early relapse of 1p/19q codeleted anaplastic oligodendroglioma with this distribution of metastases has never been described in the literature.
Conclusions: FMISO PET added more diagnostic values in differentiation between high-grade glioma and low-grade glioma.
Conclusions: Although both 18F-FDG and 11C-CHO PET/CT have value in the evaluation of ring-enhanced brain tumors shown on MRI, 11C-CHO PET/CT is more accurate. A combined use of the both tracers can improve the accuracy of the diagnosis of ring-enhanced lesions on brain MRI.
Conclusion: This preliminary study suggests that 64CuCl2 is accumulating in some but not all high-grade brain tumors. There appears to variability in the grade of Copper uptake in all grades of tumors. More data is being accumulated to define the cutoff of copper uptake as potential differentiating features for identifying possible theragnostic targets.
Conclusions: This study presents the comparison of a voxel based analysis of 18F-DOPA PET/CT and MRI in glioma patients. The mismatch between 18F-DOPA and MRI parameters indirectly confirms the hypothesis of different biological parameters identified by 18F-DOPA and MRI. Acknowledgement: This study supported by funding from the Science Development Foundation under the President of the Republic of Azerbaijan [Grant EIF/GAM-4-BGM-GIN-2017-3(29)-19/13/3]
Conclusion: The efficacy of brainstem gliomas—treated with CyberKnife is efficacious with mild toxicity. Introduction Brainstem gliomas (BSGs) account for 5–15% of brain tumors and more likely happen in children (1). BSGs constitute at least 20% of childhood brain neoplasms (2), and the peak age is 7–9 years. In contrast, BSGs is rare in the adult population and account for only 1.5–2.5% of brain glioma, with a peak age of 40–70 years (1). Diffuse intrinsic pontine glioma(DIPG) was the most common type of BSG is that could invade the whole brainstem including midbrain, pons as well as me...
ConclusionsAmino acid uptake as assessed by [18F]FET-PET/CT imaging is useful as non-invasive read-out for tumor biology and prognosis in newly diagnosed, treatment-naive gliomas according to the 2016 WHO classification.