The nervous system: a new target in the fight against cancer

During cancer progression, tumor cells interact with the neighboring environment, including neuronal tissue. The important influence of the nervous system on growth and metastasis of cancer is now widely accepted. As such, using medications that traditionally target the nervous system may be an avenue toward treating cancer. The focus of this review is to detail how several classes of medications, traditionally used to treat nervous system disorders, impact cancer. Specifically, we review the preclinical and clinical evidence that support the use of anti-β-adrenergic, anticholinergic, antipsychotic, and antidepressant medications to treat some cancers. In addition, we discuss the use of ablative modalities, such as physical and chemical denervation, to treat cancer or protect against cancer development. Using the medications that target the nervous system to treat cancer is a promising addition to an existing therapy or an alternative treatment strategy. Furthermore, rapidly expanding basic science research in this area will likely yield novel cancer therapies that work by targeting the nervous system.
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: REVIEW ARTICLE Source Type: research

Related Links:

About one third of primary care providers discussed breast cancer treatment decisions with their patients, a new survey shows -- but it's not really their job.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Publication date: 19 February 2019Source: Cell Reports, Volume 26, Issue 8Author(s): Deeksha Munnur, Joanna Somers, George Skalka, Ria Weston, Rebekah Jukes-Jones, Mohammed Bhogadia, Cyril Dominguez, Kelvin Cain, Ivan Ahel, Michal MalewiczSummaryAlthough poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly understood. NR4A nuclear orphan receptors were previously linked to DSB repair; however, their function in the process remains elusive. Classically, NR4As function as transcription factors using a specialized tandem zinc-fin...
Source: Cell Reports - Category: Cytology Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.8b21968
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
ConclusionsThese findings demonstrate that aesthetic treatments for side-effects of cancer therapies can alleviate perceived distress and improve skin symptoms and HRQoL.
Source: Quality of Life Research - Category: Health Management Source Type: research
ahesh Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs may cause pandemic outbreaks and zoonotic infections with, for example, highly pathogenic avian influenza virus (HPAIV) of the H5N1 and H7N9 subtypes, which pose a threat to public health. Treatment options are limited and emergence of strains resistant to antiviral drugs jeopardize this even further. Like all viruses, IAVs depend on host factors for every step of the virus replication cycle. Host kinases link multiple signaling pathways ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Publication date: Available online 18 February 2019Source: Pharmacology &TherapeuticsAuthor(s): Alexander W. Hird, Adriana E. TronAbstractDysregulation of the mitochondrial apoptotic pathway controlled by members of the Bcl-2 protein family plays a central role in cancer development and resistance to conventional cytotoxic as well as targeted therapies. Hence, selective inhibition of pro-survival Bcl-2 family of proteins to activate apoptosis in malignant cells represents an exciting anti-cancer strategy. The remarkable clinical performance of the selective Bcl-2 antagonist venetoclax has highlighted the potential for ...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 18 February 2019Source: Pharmacology &TherapeuticsAuthor(s): Viviana I. Torres, Juan A. Godoy, Nibaldo C. InestrosaAbstractCommunication between cells occurs through secreted molecules, among which Wnt ligands play a critical role in balancing cell proliferation, differentiation and cellular homeostasis. The action of Wnt signaling can be modulated at several levels, including posttranslational modification of the Wnt ligands, whose acylation is critical for biological activity. At least three enzymes are necessary for Wnt acylation/deacylation: stearoyl CoA desaturase (SCD), porcupin...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Clinical trials for cancer patients give the opportunity for people to try the newest cancer therapies and receive exceptional care. So why do only 8% of cancer patients enroll in one?
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Gastric acid suppressants may reduce absorption of oral cancer drugs, as shown in a study with pazopanib for sarcoma in which the interaction led to worse outcomes. Can this be practice changing?Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Here are some of the latest health and medical news developments, compiled by the editors of HealthDay: Immunotherapies Prove Their Mettle Against Kidney Cancer Adding immunotherapy to targeted cancer therapy boosted survival for kidney cancer...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
More News: Brain | Cancer | Cancer & Oncology | Cancer Therapy | Chemistry | Environmental Health | Neurology | Neuroscience | Science