Atypical Presentation of PHACE Syndrome: Hidden Facial Hemangioma

PHACE(S) syndrome is a neurocutaneous syndrome with a wide array of presentations. The most known and present trait is facial hemangioma #x3e; 5 cm. The name is an acronym forPosterior fossa malformations, infantileHemangiomas,Arterial anomalies, aorticCoarctation,Eye abnormalities, and middle-line malformations of theSternum. The exact etiopathogenic mechanism of this syndrome is not fully understood, and its treatment depends on detailed and individualized assessment. The aim of this paper is to describe a child with a throat hemangioma, vascular malformations, cognitive delay, and other anomalies to illustrate the neuroimaging found in this syndrome.Pediatr Neurosurg
Source: Pediatric Neurosurgery - Category: Neurosurgery Source Type: research

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Conclusions: SWS affects approximately 0.19/100,000/year in Olmsted County. Early diagnosis, intervention, lifelong follow-up, and multidisciplinary approach should be used to optimize systemic and ocular outcomes. PMID: 32233696 [PubMed - as supplied by publisher]
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
CONCLUSIONS: Because RCHs vary in size, the degree of inflammation, and symptoms, this disorder should be actively treated on a case-by-case basis. Fluorescein angiography should be used periodically to determine recurrence of the tumor or inflammation, and the appropriate treatment should be repeated as necessary. Moreover, regular systemic screening tests for von Hippel-Lindau disease should be performed in RCH patients to ensure that they have no abnormalities other than in the eye. PMID: 32233147 [PubMed - in process]
Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
In this report, we describe the case of a 58-year-old woman who presented with hematochezia and who was diagnosed with small bowel hemangioma. She was successfully treated using endoscopic sclerotherapy. Initial capsule endoscopy revealed bleeding in the ileum. Subsequent double-balloon enteroscopy showed a 2-cm, bluish-purple, ileal submucosal tumor with an overlying protrusion. The lesion was responsible for the hematochezia and was treated with intralesional injection of polidocanol. The hematochezia completely resolved and at 4 months after sclerotherapy, the size of the lesion was significantly reduced. PMID: 3223...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
We report a case of capillary hemangioma of lobular subtype in the calvarium of a 28-year-old pregnant woman which presented as a sore and rapidly growing bulge over the left fronto-parietal region. Magnetic resonance imaging of the brain and skull showed an expansive tumor with brain displacement, skull erosion, and scalp infiltration. The tumor was surgically removed, and histopathological examination showed a capillary hemangioma of lobular subtype. To the best of our knowledge, this is the first report of a lobular capillary hemangioma in the calvarium, and it represents a rarity to be considered among the many other d...
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
AbstractA 50 ‐ to 65‐year‐old female, from the Roman period Kellis 2 (K2) cemetery in the Dakhleh Oasis, Egypt, shows macroscopic and imaging evidence of a vertebral haemangioma (VH). The centrum of the 12th thoracic vertebrae has an expanded and lysed cortex and thickened vertical trabeculae—producing t he pathognomonic “corduroy” radiological sign. Additionally, the first lumbar vertebrae shows early changes of haemangioma that are not obvious macroscopically but clear on the X‐ray and the microcomputed tomography (μCT) imaging. VHs are relatively common (>10%) benign vascular tumours in e...
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
radRounds Radiology Network and Idonia are partnering to provide a professional Image Exchange Platform to facilitate collaboration, exchange and research on COVID-19 cases.Users can upload, store, organize, review, and share DICOM Images.Idonia is a secure (HIPAA compliant) online platform for medical image exchange and delivery. The platform can serve as a repository for relevant clinical cases, which radiologists can access and visualize thanks to the DICOM viewer of the platform. This allows radiologists to create their own network to collaborate and share relevant cases with other radiologists.Idonia and radRounds hav...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Conclusion: The response to propranolol treatment in IH patients was associated with the gene polymorphism of CYP2D6 (rs1135840). A low-dose propranolol regimen was effective and safe in young infants with IH. The change of serum VEGF levels after one month's treatment could not be used to predict the response rate to propranolol. PMID: 32219146 [PubMed - as supplied by publisher]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Epigenomics, Ahead of Print.
Source: Future Medicine: Epigenomics - Category: Genetics & Stem Cells Authors: Source Type: research
Purpose: To evaluate the subfoveal choroidal thickness (SFCT) and vascular architecture in the fellow eyes of patients with circumscribed choroidal hemangioma (CCH). Methods: In this retrospective observational study, patients were selected from outpatient ophthalmology clinics at the Memorial Sloan Kettering Cancer Center and Vitreous Retina Macula Consultants of New York. Subfoveal choroidal thickness was measured using enhanced depth imaging spectral domain optical coherence tomography from the outer portion of Bruch membrane to the choroidal–scleral interface. Choroidal vascular architecture was qualitativel...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Abstract Infantile hemangiomas (IHs) are common benign vascular tumours in infants (estimated prevalence 5% to 10%).1 Oral propranolol is currently the first-line treatment for complicated proliferative IHs.2 It is approved by the US Food and Drug Administration and the European Medicines Agency for treating complicated IHs, but questions remain regarding the optimal modalities of use.3 We conducted an international survey to assess practices in prescribing oral propranolol for IHs among practitioners dealing with IHs worldwide. PMID: 32221977 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
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