Tailoring the AAV2 capsid vector for bone-targeting.
CONCLUSION: Inserting a bone-targeting peptide into the vector capsid increases gene delivery and expression in the bone without decreasing enzyme expression. This approach could be a novel strategy to treat systemic bone diseases.
PMID: 30323349 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Alméciga-Díaz CJ, Montaño AM, Barrera LA, Tomatsu S Tags: Pediatr Res Source Type: research