Systemic bone loss, impaired osteogenic activity and type I muscle fiber atrophy in mice with elastase-induced pulmonary emphysema: Establishment of a COPD-related osteoporosis mouse model
Although it is suggested that chronic obstructive pulmonary disease (COPD) and bone are related, almost all of the pathological mechanisms of COPD-related osteoporosis remain unknown. There is a mouse model showing a deterioration of bone quality after cigarette smoke exposure; however, in smoking exposure models, various factors exist that affect bone metabolism, such as smoking and body weight loss (muscle and fat mass loss). We considered it appropriate to use an elastase-induced emphysema model to exclude factors influencing bone metabolism and to investigate the influence of pulmonary emphysema on bone metabolism.
Source: Bone - Category: Orthopaedics Authors: Manabu Tsukamoto, Toshiharu Mori, Ke-Yong Wang, Yasuaki Okada, Hokuto Fukuda, Keisuke Naito, Yoshiaki Yamanaka, Ken Sabanai, Eiichiro Nakamura, Kazuhiro Yatera, Akinori Sakai Tags: Full Length Article Source Type: research
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