Synthetic Neoepitopes of the Transglutaminase –Deamidated Gliadin Complex as Biomarkers for Diagnosing and Monitoring Celiac Disease

Celiac disease has characteristics of an autoimmune disease, such as increased antibody levels to tissue transglutaminase (tTG). However, assays to measure these biomarkers in blood samples do not identify patients with sufficient accuracy for diagnosis or monitoring of celiac disease. We aimed to discover biomarkers of celiac disease derived from neoepitopes of deamidated gliadin peptides (DGP) and tTG fragments and to determine if immune reactivity against these epitopes can identify patients with celiac disease with mucosal healing.

Source: Gastroenterology - October 17, 2018 Category: Gastroenterology Authors: Rok Seon Choung, Shahryar Khaleghi Rostamkolaei, Josephine M. Ju, Eric V. Marietta, Carol T. Van Dyke, J.J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Karenah E. Rajasekaran, Karthik Krishna, Hari Krishnan Krishnamurthy, Joseph A. Murray Source Type: research