Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B e Antigen in Individuals With Chronic Hepatitis B Virus Infection

For chronic hepatitis B patients, hepatitis B e antigen (HBeAg) seroclearance signals a transition from an immunologically active phase to an inactive carrier state with a reduction in hepatitis B virus (HBV) DNA levels and a reduced risk of hepatocellular carcinoma (HCC).1 Predictors of HBeAg seroclearance include lower HBV DNA levels, viral genotype, the precore mutation, and higher serum alanine aminotransferase (ALT) levels.2

Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Jessica Liu, Hui-Han Hu, Chia-Ling Chang, Chin-Lan Jen, Mei-Hsuan Lee, Sheng-Nan Lu, Li-Yu Wang, Quan Yuan, Ning-Shao Xia, Masaya Sugiyama, Nao Nishida, Masashi Mizokami, Chien-Jen Chen, Pei-Jer Chen, Hwai-I. Yang Tags: Research Correspondence Source Type: research