Somatostatin receptor expression in non-classical locations - clinical relevance?

Somatostatin receptor expression in non-classical locations - clinical relevance?
Rev Endocr Metab Disord. 2018 Oct 15;:
Authors: Bhanat E, Koch CA, Parmar R, Garla V, Vijayakumar V
Abstract
In-111 pentetreotide (Octreoscan) is a radiolabeled somatostatin analog with high binding affinity to somatostatin receptors (SSTR) used in somatostatin receptor scintigraphy (SRS). Pentetreotide labelled with In-111 is widely used due to its high affinity to SSTR 2 and 5. SSTR are expressed on neuroendocrine cells as well as several non-neural and non-endocrine cells with varying levels of density. We retrospectively reviewed articles and publications related to octreoscan accumulation in sites that classically do not have high concentrations of SSTR as well as in organs and tissues from diseases which are not usually diagnosed by octreoscan. The significance of a positive uptake as assessed by octreoscan in non-somatostatin receptor related diseases is not fully understood yet. Localization of octreotide in non-oncological disease states such as inflammation is due to presence of SSTR in activated immunological cells, over-expression by activated cells in the respective tissue and SSTR expression by blood vessels. In granulomatous diseases, over-expression of SSTR2 preferential binding sites were detected in epitheloid and giant cells. The purpose of the current study is to identify octreoscan localization in non-somatostatin receptor related d...

Source: ENDOCR REV - October 15, 2018 Category: Endocrinology Authors: Bhanat E, Koch CA, Parmar R, Garla V, Vijayakumar V Tags: Rev Endocr Metab Disord Source Type: research