Relationship between allostatic load and clinical outcomes in youth at ultra-high risk for psychosis in the NEURAPRO study
Individuals at ultra-high risk (UHR) for psychosis have an elevated risk of developing psychosis and other psychiatric outcomes. Risk biomarkers can assist in delineating individual risk and allow better prediction of longer-term outcomes. The aim of the present study was to examine if allostatic load (AL), a multisystem index of neuroendocrine, cardiovascular, immune and metabolic dysregulation, is associated with clinical outcomes in youth at UHR for psychosis.AL was measured in 106 participants of the NEURAPRO study (n = 70 female, n = 36 male; mean age 17.21, SD 2.37), a multicentre randomized-controlled trial of long-chain omega-3 polyunsaturated fatty acids versus placebo in people at UHR for psychosis.
Source: Schizophrenia Research - Category: Psychiatry Authors: Maximus Berger, Suzie Lavoie, Patrick D. McGorry, Barnaby Nelson, Connie Markulev, Hok-Pan Yuen, Miriam Schaefer, Zolt án Sarnyai, G. Paul Amminger Source Type: research
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