Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy

Publication date: Available online 16 October 2018Source: Epilepsy & Behavior Case ReportsAuthor(s): Takefumi Hitomi, Morito Inouchi, Katsuya Kobayashi, Shamima Sultana, Takeshi Inoue, Yuko Nakayama, Akihiro Shimotake, Masao Matsuhashi, Riki Matsumoto, Kazuo Chin, Ryosuke Takahashi, Akio IkedaAbstractTo clarify the effects of sleep on cortical irritability in benign adult familial myoclonus epilepsy (BAFME). We retrospectively compared epileptiform discharges of electroencephalographies (EEGs) between awake and sleep periods in 5 patients (mean age: 49.6 ± 20.3 years). We also analyzed polysomnography (PSG) of 1 patient (59 years-old). Epileptiform discharges were significantly more frequent during awake period (1.3 ± 1.2 / min) than those during light sleep stages (0.02 ± 0.04 / min) (P < 0.05). Regarding PSG analysis, epileptiform discharges also reduced during all sleep stages compared to those during awake period. Our study indicated a reduction in cortical irritability during sleep in BAFME.
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research