Quantitative and Qualitative Comparison of EEG-Based Neural Network Organization in Two Schizophrenia Groups Differing in the Duration of Illness and Disease Burden: Graph Analysis With Application of the Minimum Spanning Tree.

Quantitative and Qualitative Comparison of EEG-Based Neural Network Organization in Two Schizophrenia Groups Differing in the Duration of Illness and Disease Burden: Graph Analysis With Application of the Minimum Spanning Tree. Clin EEG Neurosci. 2018 Oct 16;:1550059418807372 Authors: Jonak K, Krukow P, Jonak KE, Grochowski C, Karakuła-Juchnowicz H Abstract The aim of this study was to compare neural network topology of 30 patients with first episode schizophrenia (FES) and 30 multiepisode schizophrenia (mean number of psychotic relapses =4 years, duration of illness >5 years) patients, who were assessed with graph theory methods. This comparison was designed to identify network differences, which might be assigned to the burden of a mental disease. To estimate functional connectivity, we applied the phase lag index algorithm and the minimum spanning tree (MST) for the characterization of network topology. Group comparison revealed significant between-group differences of maximal betweenness centrality and tree hierarchy in the beta-band and hierarchy in the gamma-band. MST results showed that in the beta-band the network of patients with longer duration of illness (LDI) was characterized by more centralized network, while subjects with short duration of illness (FES) showed more decentralized topology. Furthermore, in the gamma-band, our results suggest that illness duration can disturb the balance between overload prevention an...
Source: Clinical EEG and Neuroscience - Category: Neuroscience Authors: Tags: Clin EEG Neurosci Source Type: research