Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy.

Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy.
Biochimie. 2018 Oct 13;:
Authors: Malhotra A, Sharma U, Puhan S, Chandra Bandari N, Kharab A, Arifa PP, Thakur L, Prakash H, Vasquez KM, Jain A
Abstract
The five-year survival rate of esophageal cancer patients is less than 20%. This may be due to increased resistance (acquired or intrinsic) of tumor cells to chemo/radiotherapies, often caused by aberrant cell cycle, deregulated apoptosis, increases in growth factor signaling pathways, and/or changes in the proteome network. In addition, deregulation in non-coding RNA-mediated signaling pathways may contribute to resistance to therapies. At the molecular level, these resistance factors have now been linked to various microRNA (miRNAs), which have recently been shown to control cell development, differentiation and neoplasia. The increased stability and dysregulated expression of miRNAs have been associated with increased resistance to various therapies in several cancers, including esophageal cancer. Therefore, miRNAs represent the next generation of molecules with tremendous potential as biomarkers and therapeutic targets. Yet, a detailed studies on miRNA-based therapeutic intervention is still in its infancy. Hence, in this review, we have summarized the current status of microRNAs in dictating the resistance/sensitivity of tumor cells against chemotherapy and radiotherapy. I...

Source: Biochimie - October 13, 2018 Category: Biochemistry Authors: Malhotra A, Sharma U, Puhan S, Chandra Bandari N, Kharab A, Arifa PP, Thakur L, Prakash H, Vasquez KM, Jain A Tags: Biochimie Source Type: research