Activity of Meropenem-Vaborbactam Against Pseudomonas aeruginosa and Acinetobacter baumannii in a Neutropenic Mouse Thigh Infection Model.
Activity of Meropenem-Vaborbactam Against Pseudomonas aeruginosa and Acinetobacter baumannii in a Neutropenic Mouse Thigh Infection Model.
Antimicrob Agents Chemother. 2018 Oct 15;:
Authors: Sabet M, Tarazi Z, Griffith DC
Abstract
We have evaluated the activity of meropenem-vaborbactam against clinical isolates of Pseudomonas aeruginosa and Acinetobacter baumannii in a neutropenic mouse thigh infection model. Data show that meropenem-vaborbactam regimens equivalent to 3-hour infusions every 8 hours with 2g meropenem-2g vaborbactam produced bacterial killing against strains with MICs of 2 - 16 mg/L and suggests that this combination may have utility in the treatment of infections caused by P. aeruginosa and A. baumannii.
PMID: 30323049 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Sabet M, Tarazi Z, Griffith DC Tags: Antimicrob Agents Chemother Source Type: research
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