Probiotic supplementation and topical application in the treatment of pediatric atopic dermatitis.

Probiotic supplementation and topical application in the treatment of pediatric atopic dermatitis. Curr Pharm Biotechnol. 2018 Oct 08;: Authors: Marcinkowska M, Zagorska A, Fajkis N, Kołaczkowski M, Pasko P Abstract Atopic dermatitis is a chronic inflammatory skin disease that commonly presents in early childhood. To date, the pharmacological treatment of atopic dermatitis is far from ideal, poses several limitations and constantly requires novel approaches. The theory that appropriate colonization of gut bacteria during infancy, influences the development of the immune system has initiated numerous clinical trials that evaluated the effectiveness of probiotic supplementation for the prevention and treatment of atopic eczema in children. In addition, topical administration of probiotics has demonstrated the ability to improve the skin's barrier function, which might contribute to reductions in the severity of atopic dermatitis. In this article, we review the literature and data regarding the use of probiotics, both by oral administration and topical application, in the treatment of atopic dermatitis. Moreover, we summarize the knowledge regarding the potential mechanisms by which probiotics influence the gut and exert their skin effects. Probiotic supplementation seems to be an attractive strategy regarding prevention and treatment of pediatric atopic dermatitis. However, to provide full effectiveness, the period of supplementation ...
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research