Giant cell carcinoma of the lung successfully treated with surgical resection and adjuvant vinorelbine and cisplatin

Publication date: Available online 17 October 2018Source: Respiratory Medicine Case ReportsAuthor(s): Saad Habib, Lazer Ezriel Leifer, Mohammed Azam, Abdul Hasan Siddiqui, Kartikeya Rajdev, Michel ChalhoubAbstractGiant Cell Carcinoma of the lung, a subtype of Sarcomatoid lung cancer is a poorly differentiated Non-Small-Cell Lung Cancer. GCCL has exceptionally aggressive characteristics, and its prognosis is much poorer than any other NSCLCs. Herein, we present a rare case of Giant Cell Carcinoma of lung treated successfully with surgical resection and adjuvant vinorelbine and cisplatin.A 48-year-old African American man with a history of smoking and chronic obstructive pulmonary disease was admitted to the hospital for chief complaints of shortness of breath. He was found to have a 3.5 cm × 3.3 cm x 2.8 cm cavitary right upper lobe mass which turned out to be poorly differentiated Giant Cell Carcinoma with extensive necrosis and deemed similar to stage 1b non-small cell lung cancer. He was successfully treated with right upper lobectomy and adjuvant chemotherapy with vinorelbine and cisplatin. He was followed for seven years with no evidence of recurrent disease.Giant Cell Carcinoma's existing literature is limited, and hence our case is reportable. Our case is unique because of the better outcome which we believe might be the result of early detection and treatment with surgical resection along with adjuvant chemotherapy. More studies are needed to deeply under...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research

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Conclusions: Robotic pulmonary resection proved to be a safe treatment for lung cancer. Longer follow-up periods are required in order to assess long-term survival.RESUMO Objetivo: Descrever morbidade, mortalidade e completude da ressec ção associadas à cirurgia robótica para o tratamento de câncer de pulmão não pequenas células no Brasil, assim como sobrevida global e sobrevida livre de doença. Métodos: Estudo retrospectivo incluindo pacientes com diagnóstico de carcinoma pulmonar de células não pequenas submetidos à ressec&cc...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
Introduction: The relationship between lung cancer and COPD is well known. Recent clinical studies found a higher prevalence of obstructive sleep apnea (OSA) in patients suffering lung cancer. Although hypoxia has been suggested to be one of the main factors associated with lung malignancy, most studies addressing this topic have limitations due to the reduced number of patients recruited and because lung cancer has been analyzed avoiding its complexity in terms of different histotypes.Aim: to investigate the effect of different patterns of hypoxia on cells of the most prevalent histological sub-types of non-small cell lun...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
Conclusion: Five-year survival is higher in the I group (p>0.05). But mortality from cancer recurrence is lower in the II group (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
CONCLUSIONS: We have demonstrated that μs' at 800 nm is increased in the buccal mucosa of patients with lung cancer compared to controls with COPD. This might be an indication of field cancerization in the oral cavity of patients with lung cancer. PMID: 31473370 [PubMed - as supplied by publisher]
Source: Translational Oncology - Category: Cancer & Oncology Authors: Tags: Transl Oncol Source Type: research
The objective of this study was to compare survival between NSCLC patients with and without COPD.MethodsMedical records were retrospectively collected from 301 elderly patients pathologically diagnosed with NSCLC from the Chinese PLA General Hospital. Ultimately, a total of 200 patients were enrolled in the analysis. The survival rates between the COPD ‐NSCLC and non‐COPD NSCLC were assessed using log‐rank and Cox proportional hazard regression analyses.ResultsA total of 117 COPD ‐NSCLC and 93 non‐COPD NSCLC patients were enrolled in the analysis. The median overall survival times were 108.5 months in the no...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSION: To our knowledge this is the first study comparing the levels of protein and mRNA in the serum material of HGF, c-MET, EGF and EGFR parameters in lung cancer patients' blood samples. Further prospective studies with more participants for better understanding of mechanism and effect for HGF and c-MET inhibitors in lung cancer will help us to identify of these biomarkers role for guiding us to sellect individualized itargeted therapies. PMID: 31104010 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
Mark E. Gray1,2*, James Meehan2,3, Paul Sullivan4, Jamie R. K. Marland4, Stephen N. Greenhalgh1, Rachael Gregson1, Richard Eddie Clutton1, Carol Ward2, Chris Cousens5, David J. Griffiths5, Alan Murray4 and David Argyle1 1The Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom 2Cancer Research UK Edinburgh Centre and Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 3School of Engineering and Physical Sciences, Institute of Sensors, Signals and Systems, Heriot-Watt Univer...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: MiR-223 is differently expressed in plasma from LC, COPD and asthma patients. In order to ascertain its role as biomarker for discrimination of patients analysis of enlarged sampling is necessary. Funded by Medical University, Sofia, contract Nr. 90/2016.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Conclusion: Pneumonitis after SBRT occur later than after CRT. Although a high percentage of the patients receiving curatively intended radiotherapy developed radiation pneumonitis, this was not reflected in the health related quality of life as measured by CCQ.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Conclusion: There was no impact of COPD and BMI on the survival rate. Although considered to have common causative factor, in this cohort we did not find the impact of coexisting COPD and high BMI on survival in advanced NSCLC. Further examination of low BMI on NSCLC survival should be explored.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
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