miR-34c disrupts spermatogonial stem cell homeostasis in cryptorchid testes by targeting Nanos2.

CONCLUSIONS: The miR-34c/Nanos2 pathway provides new insight into the mechanism of male infertility caused by cryptorchidism. Our results indicate that miR-34c may serve as a biological marker for treatment of infertility caused by cryptorchidism.
PMID: 30322389 [PubMed - in process]

Source: Reproductive Biology - October 15, 2018 Category: Reproduction Medicine Authors: Huang Z, Tang D, Gao J, Dou X, Cheng P, Peng D, Zhang Y, Mao J, Zhang L, Zhang X Tags: Reprod Biol Endocrinol Source Type: research