Polyvinylpyrrolidone/hyaluronic acid-based bilayer constructs for sequential delivery of cutaneous antiseptic and antibiotic

Publication date: 15 February 2019Source: Chemical Engineering Journal, Volume 358Author(s): Marco Contardi, Debora Russo, Giulia Suarato, José A. Heredia-Guerrero, Luca Ceseracciu, Ilaria Penna, Natasha Margaroli, Maria Summa, Raffaele Spanò, Giovanni Tassistro, Luigi Vezzulli, Tiziano Bandiera, Rosalia Bertorelli, Athanassia Athanassiou, Ilker S. BayerAbstractAfter a skin injury, many complex metabolic events are triggered to ensure proper wound healing. Particularly for chronic, non-healing wounds or burns several risk factors such as persistent bacterial infections and fast dehydration can counteract the healing process. Intelligent wound dressings should help accelerate the healing process, while maintaining the wound bed clean and disinfected for several days at a time. Ideally, they should be self-adherent to both moist and dry skin surfaces and be transparent enough to allow prolonged wound inspection. These requirements pose challenges both in terms of materials science and pharmaceutics. Herein, we describe fabrication of a transparent bilayer construct for the sequential release and delivery of a cutaneous antiseptic and a widely used antibiotic, potentially suitable for wound dressing applications. The fabrication is a scalable waterborne and ecofriendly solution casting process. The first layer (for direct wound contact) is polyvinylpyrrolidone (PVP) containing a commercial antiseptic, Neomercurocromo® (Neo), while the second layer is a blend of hyaluronic aci...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research