Sexual behavior: From hormonal regulation to endocrine disruption

Sexual behavior constitutes a chain of behavioral responses beginning with courtship and leading to copulation. These responses, which are exhibited in a sexually dimorphic manner by the two partners, are tightly regulated by sex steroid hormones as early as the perinatal period. Hormonal changes or exposure to exogenous factors exhibiting hormone-mimetic activities such as endocrine disrupting compounds (EDC) can therefore interfere with their expression. Here we review the experimental studies in rodents performed to address the potential effects of exposure to EDC on sexual behavior and underlying mechanisms, with a particular attention to molecules with estrogenic and/or anti-androgenic activities.
Source: Neuroendocrinology - Category: Endocrinology Source Type: research

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Publication date: Available online 22 April 2019Source: Progress in Natural Science: Materials InternationalAuthor(s): Xin Liu, Guang Feng, Yu Zhou, Qunbo FanAbstractA novel method for the analysis of composition distribution of titanium alloys over a large area (64 mm × 72 mm) was investigated by exploring the original position statistic distribution based on spark spectrum (OPA-SS) in Ti-6.5Al-1.0Cr-0.5Fe-6.0Mo-3.0-Sn-4.0Zr titanium alloy. The results showed that OPA-SS could characterize the distribution of elements in different positions on the titanium alloy. The macrosegregation of Sn was the most prono...
Source: Progress in Natural Science: Materials International - Category: Materials Science Source Type: research
Publication date: Available online 21 April 2019Source: Materials Science and Engineering: AAuthor(s): L.G. Vettraino, M. Zhang, J.L.W. Carter, J.R. Groza, J.C. GibelingAbstractSteady-state creep behavior of rolled Cu-8Cr-4Nb (GRCop-84) production sheet was systematically studied at temperatures from 673 to 1073 K (0.50–0.79 Tm). Threshold behavior was observed at high temperatures and low stresses which can be phenomenologically described by a threshold stress model. The threshold stress obtained by a non-linear regression method ranges from 0.2∼0.3 of the Orowan stress, which suggests that dislocations locall...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Publication date: Available online 21 April 2019Source: Materials Science and Engineering: AAuthor(s): Heng Zhang, Ke Xin Jiao, Jian Liang Zhang, Jianping LiuAbstractThis paper presents a systematic study of the differences in the microstructures and micro-mechanical properties of various Cu/Fe wave interfaces prepared by explosive welding. These wave interfaces, fabricated by different parameters, have been divided into four categories according to variations in their microstructures and the element distribution: vortex region, transition layer, interface without metal bonding, and interface with defects. In the wave inte...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Publication date: 15 August 2019Source: Materials Letters, Volume 249Author(s): Guangtao Liu, Zhenhai Yu, Shourui Li, Hongbo WangAbstractTo date, the exact structure of PtH, the key to resolve the controversial hexagonal close-packed (hcp) phase of SiH4, is still absent above 100 GPa. Therefore, PtH has been synthesized and its compression behavior is determined through the angle dispersive X-ray diffraction method. We find that hcp PtH keeps stable up to at least 128 GPa and its experimental lattice parameters are highly consistent with those of the hcp one in the SiH4 experiment. The present results provide reliable ...
Source: Materials Letters - Category: Materials Science Source Type: research
In this study, we experimentally investigate the evolution of the Raman spectrum of single, bi- and tri-layer graphene as function of gate voltage induced doping. In single layer graphene, the observed results are in agreement with the literature. Whereas, for bi- and tri-layer graphene, we report new results on the gate voltage induced doping dependence of G and 2D bands position, the 2D to G band intensity ratio and the G band linewidth. The gate bias through 90 nm-thick oxide allows us to move the Fermi level up to 0.43 eV and 0.31 eV for bi- and tri-layer graphene, respectively. We observe one minima in the evolu...
Source: Carbon - Category: Materials Science Source Type: research
We examined the prevalence and effect on conversion of SPD in a cohort of 218 individuals whose symptoms met APS criteria. Results indicated that SPD was highly prevalent (68%), and that SPD did not influence risk for conversion. Rather, total positive symptom burden measured by the Structured Interview for Psychosis-Risk Syndromes (SIPS; OR 1.12, p=0.02) emerged as the strongest predictor of conversion. These data suggest that when encountering a patient whose presentation meets SPD criteria, the clinician should assess whether APS criteria are also met and, for 1-2 years, carefully monitor positive symptoms for possible ...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 22 April 2019Source: Seminars in Cell &Developmental BiologyAuthor(s): Débora G. Souza, Roberto F. Almeida, Diogo O. Souza, Eduardo R. ZimmerAbstractAstrocytes are a unique and dynamic subtype of glial cells in the central nervous system (CNS). Understanding their biochemical reactions and their influence in the surrounding cells is extremely important in the neuroscience field. They exert important influence in the neurotransmission, ionic homeostasis and also release neuroactive molecules termed gliotransmitters. Additionally, they metabolize, store and release metabolic subs...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
CONCLUSIONS Matricine induced antiproliferative effects in capan-2 human pancreatic cancer cells through inducing apoptosis, caspase activation, inhibition of cell migration and invasion, and blocking the mTOR/PI3K/AKT signalling pathway. PMID: 31005960 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS In conclusion, in view of the results of this study, it might be suggested that ferruginol might serve as an essential lead molecule for the treatment of thyroid cancer provided further in-depth studies especially studying ferruginol toxicological as well as in vivo studies are needed. PMID: 31005958 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Tian S, Yan Y, Qi X, Li X, Li Z Abstract BACKGROUND Rheumatoid arthritis model (CIA) rats were treated by tail vein injection of IL-10-modified bone marrow mesenchymal stem cells (BMSCs) to investigate its feasibility and intrinsic molecular mechanism. MATERIAL AND METHODS The CIA rat model was established by induction type II collagen, and IL-10-modified BMSCs was established by transfecting BMSCs with adenovirus. IL-10-modified BMSCs were used to treat the CIA rats. The therapeutic effect was evaluated by measuring the changes in body weight, ankle swelling, and forced swimming time, as well as observati...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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