Endospanin 1 determines the balance of leptin-regulated hypothalamic functions
Endospanin 1 (Endo1), a protein encoded, in humans by the same gene than the leptin receptor (ObR), and increased by diet induced obesity, is an important regulator of ObR trafficking and cell surface exposure, determining leptin signaling strength. Defective intracellular trafficking of the leptin receptor to the neuronal plasma membrane has been proposed as a mechanism underlying the development of leptin resistance observed in human obesity. More recently, Endo1 has emerged as a mediator of "selective leptin resistance". The underlying mechanisms of the latter are not completely understood, but the possibility of differential activation of leptin signaling pathways was suggested among others. In this respect, the expression level of Endo1 is crucial for the appropriate balance between different leptin signaling pathways and leptin functions in the hypothalamus, and is likely participating in selective leptin resistance for the control of energy and glucose homeostasis.
Publication date: February 2019Source: Cancer Epidemiology, Volume 58Author(s): Aleyamma Mathew, Preethi Sara George, Jagathnath Krishna K M, Durga Vasudevan, Francis V. JamesAbstractBackground &objectivesAn assessment of transition of cancer in India during the past 30 years, according to changes in demographic and epidemiologic risk factors was undertaken.Materials &methodsCancer registry data (http://www.ncdirindia.org), (population coverage
After decades of research, there are shockingly few firm conclusions.
By HANS DUVEFELT MD I have seen the light. I now, finally, see a clear role for artificial intelligence in health care. And, no, I don’t want it to replace me. I want it to complement me. I want AI to take over the mandated, mundane tasks of what I call Metamedicine, so I can concentrate on the healing. In primary care visits in the U.S., doctors and clinics are buried in government mandates. We have to screen for depression and alcohol use, document weight counseling for every overweight patient (the vast majority of Americans), make sure we probe about gender at birth and current gender identification, offer ...
MONDAY, Dec. 10, 2018 -- Transplant patients with hearts from donors with hepatitis C virus (HCV) infection and obese donors have similar survival rates as patients with other donor hearts, according to two studies published in the December issue...
Coffee and green tea are two of most usual consumed beverages in the world which have several beneft components. Coffee and green tea have signifcantly inverse correlation with obesity, diabetes, and cardiovascular diseases. Adiponectin and leptin are the adipokines mostly secreted from adipose tissue and play the important roles on the status of chronic diseases. In the present study, we aimed to review the evidence about relationship between these beverages and adiponectin and leptin levels.We searched in PubMed to January 2013 using several key words such as coffee, green tea, caffeine, leptin, adiponectin, and adipokin...
(Florida Atlantic University) Researchers have discovered what might be an effective strategy to prevent and combat cognitive dysfunction in obese individuals. They are the first to examine the modulatory role of an exercise-induced protein in the brain that promotes neuron survival and used high-intensity interval exercise (HIIE) in obese and normal-weight subjects. Obesity reduces the expression of this protein and lower levels are associated with Alzheimer's, Parkinson's and obesity. HIIE upregulated this protein in the obese subjects compared to normal-weight subjects.
Discussion Intrauterine growth retardation or fetal growth retardation is due to a pathological process that causes decelerated fetal growth velocity. Small-for-gestational age (SGA) is an infant with growth parameters below the normal range for gestational age. More commonly, SGA is defined as a birth weight
This study suggests that obesity, advancing age, a family history of diabetes and living in a rural area are important drivers of the escalating prevalence of type 2 diabetes in Malaysia.
ConclusionOrlistat administration reduced visceral fat area, waist circumference, and body weight in Japanese participants with excessive visceral fat and without metabolic diseases. In addition, safety was confirmed with a tolerable profile. Orlistat may be useful to reduce excessive visceral fat accumulation when used in combination with diet and exercise.Trial RegistrationJapan Pharmaceutical Information Center identifier, JapicCTI-184005.FundingTaisho Pharmaceutical Co., Ltd.
ANT2 mediates hypoxia and inflammation in obesity, Published online: 10 December 2018; doi:10.1038/s41574-018-0140-zANT2 mediates hypoxia and inflammation in obesity