Endospanin 1 determines the balance of leptin-regulated hypothalamic functions

Endospanin 1 (Endo1), a protein encoded, in humans by the same gene than the leptin receptor (ObR), and increased by diet induced obesity, is an important regulator of ObR trafficking and cell surface exposure, determining leptin signaling strength. Defective intracellular trafficking of the leptin receptor to the neuronal plasma membrane has been proposed as a mechanism underlying the development of leptin resistance observed in human obesity. More recently, Endo1 has emerged as a mediator of "selective leptin resistance". The underlying mechanisms of the latter are not completely understood, but the possibility of differential activation of leptin signaling pathways was suggested among others. In this respect, the expression level of Endo1 is crucial for the appropriate balance between different leptin signaling pathways and leptin functions in the hypothalamus, and is likely participating in selective leptin resistance for the control of energy and glucose homeostasis.
Source: Neuroendocrinology - Category: Endocrinology Source Type: research

Related Links:

Publication date: Available online 21 April 2019Source: PeptidesAuthor(s): Kate L. Lee, Jacqueline F. Aitken, Huai-L Hsu, Geoffrey M. Williams, Margaret A. Brimble, Garth J.S. CooperAbstractPancreatic islet-derived peptide hormones play key roles in the maintenance of systemic energy homeostasis and glucose balance, and defects in their regulation are strongly implicated in the pathogenesis of obesity and diabetes. Peptides have also been used as lead compounds for therapeutics targeting metabolic disease. It is therefore important to understand the activity and function of islet hormones in both their target tissues and t...
Source: Peptides - Category: Biochemistry Source Type: research
This study systematically reviewed scientific evidence regarding the impact of built environment on PA and obesity among children and ado...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
CONCLUSION: This study finds that yoga and meditation are used by middle-to-higher aged Australian women with chronic illnesses. The lack of communication with health care providers is concerning and might hinder coordinated and effective health care around chronic illness. Further research is necessary to help understand possible concurrent health care use and thereby help inform safe, effective and coordinate health seeking amongst those with chronic illness. PMID: 31003661 [PubMed - in process]
Source: Complementary Therapies in Clinical Practice - Category: Complementary Medicine Authors: Tags: Complement Ther Clin Pract Source Type: research
This study examined the effects of auricular acupressure on reducing obesity in adolescents. MATERIALS AND METHODS: Participants were 58 obese adolescents, divided into an experimental (n = 32) and a control group (n = 26). The study design was a randomized controlled trial. Auricular acupressure using vaccaria seeds was administered to the experimental group, while placebo auricular acupressure using vaccaria seeds was administered to the control group. Sessions continued for 8 weeks. Outcome measures included body weight, abdominal circumference, hip circumference, waist-hip ratio, body-mass index, body-fat ...
Source: Complementary Therapies in Clinical Practice - Category: Complementary Medicine Authors: Tags: Complement Ther Clin Pract Source Type: research
Conditions:   Adolescent Obesity;   Obesity in Adolescence;   Adolescent Overweight Interventions:   Drug: VI-0521 oral capsule;   Drug: Placebo oral capsule Sponsor:   VIVUS, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionWe have shown that, BMI is associated with poor cognitive performance in some tests which, MACFIMS battery was included. This could suggest that obesity might be an important factor, which have effect on the cognitive performance.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Working the night shift could cause some long-term health problems, like obesity, heart attacks and strokes, as well as more immediate issues, like inattention.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news
(Medical College of Georgia at Augusta University) Obesity can break down our protective blood brain barrier resulting in problems with learning and memory, scientists report.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 20 April 2019Source: Social Science ResearchAuthor(s): Anthony David Campbell, Elizabeth H. BakerAbstractThose with higher incomes tend to have better health outcomes, including healthy weight status. We use data from the 2003–2008 National Health and Nutrition Examination Survey (NHANES) to examine whether the association between higher weight status and social integration varies by income. We examine gender differences in weight status, measured by BMI and obesity, by social integration and income, and find evidence that high social integration is a risk factor for higher weight s...
Source: Social Science Research - Category: Psychiatry & Psychology Source Type: research
ConclusionsThis study highlights factors including but not limited to public greenspace, which inform obesity interventions for women of childbearing age in New Zealand.
Source: International Journal of Public Health - Category: International Medicine & Public Health Source Type: research
More News: Brain | Diets | Eating Disorders & Weight Management | Endocrinology | Genetics | Neurology | Nutrition | Obesity