Researchers determine how contraction leads to hypertrophic cardiomyopathy

Individual myosin molecules and rod-like filaments inside muscles produce less force and lower velocity of contraction, leading to hypertrophic cardiomyopathy, researcher report in a new study.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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Condition:   Hypertrophic Obstructive Cardiomyopathy Interventions:   Procedure: isolated septal myectomy;   Procedure: septal myectomy + edge-to-edge mitral valve repair;   Procedure: septal myectomy + posterior leaflet sliding plasty;   Procedure: septal myectomy + secondary chordae transection Sponsor:   Tomsk National Research Medical Center of the Russian Academy of Sciences Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
I would like to point out that in the review by Pelliccia F. [1], regarding sex differences in hypertrophic cardiomyopathy, several papers form the early stages of investigations (published in 1997 –2004), with many important findings, has not been cited [2–5]. Our pioneering studies initiated and accelerated further, more detailed studies. I feel that our group gave support for next studies, which should be emphasized. I believe that this reference would give the readers full image of sci entific progression in this area, which was based on hypothesis-generation process.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letter to the Editor Source Type: research
Authors: Horiuchi H, Doman T, Kokame K, Saiki Y, Matsumoto M Abstract The blood glycoprotein von Willebrand factor (VWF) plays an important role in hemostasis and thrombosis.VWF is produced and secreted as large multimers by endothelial cells and megakaryocytes. It is then cleaved in a sheer-stress dependent manner by a specific protease, ADAMTS13, into multimers consisting of 2-80 subunits. Among VWF multimers, high molecular weight (HMW) multimers play important roles in platelet aggregation. Therefore, their loss induces a hemostatic disorder known as von Willebrand disease (VWD) type 2A. Various cardiovascular ...
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Left ventricular assist device (LVAD) outcomes for hypertrophic (HCM) or restrictive cardiomyopathy (RCM) with a small LV are unsatisfactory due to difficulty draining via an LV apical cannula. We developed a new transeptal cannulation technique to decompress the left atrium where the atrial septum is cannulated via the right atrium.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1208 Source Type: research
Our aim was to determine the transplant-free survival for pediatric hypertrophic cardiomyopathy (HCM) patients with decreased left ventricular (LV) systolic function and identify risk factors for change in function.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1178 Source Type: research
Our objective was to provide a contemporary analysis of a pediatric hypertrophic cardiomyopathy (HCM) cohort and determine risk factors independently associated with death or heart transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1175 Source Type: research
Danon Disease (DD) is a rare genetic disorder that affects the cardiac, neurologic, and muscular systems in both men and women. Subjects affected typically develop hypertrophic cardiomyopathy (HCM) and end-stage heart failure requiring transplantation. DD is an X-linked disorder with women typically suffering milder disease presentations that develop later in life.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1170 Source Type: research
Authors: Pelliccia F, Niccoli G, Gragnano F, Limongelli G, Moscarella E, Andò G, Esposito A, Stabile E, Ussia GP, Tarantini G, Gimeno JR, Elliott P, Calabrò P Abstract Percutaneous alcohol septal ablation (ASA) is an effective and minimally invasive therapeutic strategy to resolve left ventricular outflow tract obstruction (LVOTO) in patients with hypertrophic cardiomy-opathy who remain symptomatic on maximally tolerated medical therapy. Firstly performed by Sig-wart in 1994, the procedure consists in determining an iatrogenic infarction of basal interventricular septum to reduce LVOTO and alleviate s...
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Cardiovascular phosphorus MR spectroscopy (31P-CMRS) is a powerful tool for probing energetics in the human heart, through quantification of phosphocreatine (PCr) to adenosine triphosphate (ATP) ratio. In princip...
Source: Journal of Cardiovascular Magnetic Resonance - Category: Radiology Authors: Tags: Technical notes Source Type: research
Contrast ‐enhanced echocardiography or cardiac magnetic resonance imaging is of value in the diagnosis of apical hypertrophic cardiomyopathy. Apical hypertrophic cardiomyopathy is rare in Caucasians, and gene negativity does not rule out the diagnosis. Risk stratification for sudden cardiac death and decis ions about anticoagulation in cases with atrial fibrillation should be based on guidelines. Key Clinical MessageContrast ‐enhanced echocardiography or cardiac magnetic resonance imaging is of value in the diagnosis of apical hypertrophic cardiomyopathy. Apical hypertrophic cardiomyopathy is rare in Caucasians, and ge...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
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