Copper inhibits peptidoglycan LD-transpeptidases suppressing {beta}-lactam resistance due to bypass of penicillin-binding proteins [Microbiology]
The peptidoglycan (PG) layer stabilizes the bacterial cell envelope to maintain the integrity and shape of the cell. Penicillin-binding proteins (PBPs) synthesize essential 4–3 cross-links in PG and are inhibited by β-lactam antibiotics. Some clinical isolates and laboratory strains of Enterococcus faecium and Escherichia coli achieve high-level β-lactam resistance by...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Katharina Peters, Manuel Pazos, Zainab Edoo, Jean-Emmanuel Hugonnet, Alessandra M. Martorana, Alessandra Polissi, Michael S. VanNieuwenhze, Michel Arthur, Waldemar Vollmer Tags: Biological Sciences Source Type: research
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