The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis [Medical Sciences]

The chemical diversity and known safety profiles of drugs previously tested in humans make them a valuable set of compounds to explore potential therapeutic utility in indications outside those originally targeted, especially neglected tropical diseases. This practice of “drug repurposing” has become commonplace in academic and other nonprofit drug-discovery efforts,...

Source: Proceedings of the National Academy of Sciences - October 16, 2018 Category: Science Authors: Jeff Janes, Megan E. Young, Emily Chen, Nicole H. Rogers, Sebastian Burgstaller-Muehlbacher, Laura D. Hughes, Melissa S. Love, Mitchell V. Hull, Kelli L. Kuhen, Ashley K. Woods, Sean B. Joseph, H. Michael Petrassi, Case W. McNamara, Matthew S. Tremblay, A Tags: Biological Sciences Source Type: research