NMDA-receptor antibodies alter cortical microcircuit dynamics [Neuroscience]

NMDA-receptor antibodies (NMDAR-Abs) cause an autoimmune encephalitis with a diverse range of EEG abnormalities. NMDAR-Abs are believed to disrupt receptor function, but how blocking this excitatory synaptic receptor can lead to paroxysmal EEG abnormalities—or even seizures—is poorly understood. Here we show that NMDAR-Abs change intrinsic cortical connections and neuronal population...

Source: Proceedings of the National Academy of Sciences - October 16, 2018 Category: Science Authors: Richard E. Rosch, Sukhvir Wright, Gerald Cooray, Margarita Papadopoulou, Sushma Goyal, Ming Lim, Angela Vincent, A. Louise Upton, Torsten Baldeweg, Karl J. Friston Tags: PNAS Plus Source Type: research