The role of PRMT1-mediated alternative splicing in dilated cardiomyopathy

(University of Tsukuba) In a study published in iScience, Professor Akiyoshi Fukamizu of the Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (University of Tsukuba, JAPAN) and the research group reported a new work on discovery of the important role of PRMT1 in dilated cardiomyopathy (DCM).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 23 March 2019Source: Revista Portuguesa de Cardiologia (English Edition)Author(s): Maria Emanuel Amaral, Pedro Epifânio, Natália Noronha, António Pires, Paula Martins, Vanda Azevedo, Eduardo Castela, Manuel J. AntunesAbstractAnomalous origin of the left coronary artery from the pulmonary artery is a rare congenital heart defect and a cause of myocardial ischemia during childhood. Most undiagnosed cases die in the first year of life as an extensive collateral network is essential for survival. The diagnosis requires a high index of clinical suspicion. The authors presen...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
We report a case of a 29-year old male with HF, dilated cardiomyopathy possibly related to myocarditis, and atrial fibrillation with reduced ejection fraction. Sacubitril/valsartan treatment was initiated after two years of standard treatment. In two years, therapy with sacubitril/valsartan led to persistence in sinus rhythm and progressive recovery of ejection fraction, functionality, and reduction of cardiac volumes. The patient is currently in good condition and has suspended diuretic therapy in the last six months. PMID: 30895821 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Authors: Severini D, Mboumi K Abstract Sacubitril/valsartan was shown to be effective in improving the clinical outcome and reducing hospitalization rate and mortality in patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF). Here we report a case series of three patients with HFrEF associated with mitral insufficiency (case #1), dilated cardiomyopathy (case #2), and chronic ischaemia (case #3). The first case was a 49-year-old male and the further two were 70-year-old male patients. After previous ineffective treatment, the administration of sacubitril/valsartan led to a rapid and...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Publication date: Available online 22 March 2019Source: MitochondrionAuthor(s): Periyasamy Govindaraj, Bindu Rani, Pandarisamy Sundaravadivel, Ayyasamy Vanniarajan, K.P. Indumathi, Nahid Akthar Khan, Perundurai S. Dhandapany, Deepa Selvi Rani, Rakesh Tamang, Ajay Bahl, Calambur Narasimhan, Dharma Rakshak, Andiappan Rathinavel, Kumpati Premkumar, Madhu Khullar, Kumarasamy ThangarajAbstractIdiopathic dilated cardiomyopathy (DCM) is a structural heart disease with strong genetic background. The aim of this study was to assess the role of mitochondrial DNA (mtDNA) variations and haplogroups in Indian DCM patients. Whole mtDNA ...
Source: Mitochondrion - Category: Biochemistry Source Type: research
ConclusionInhibition of Epac1 could be a valuable therapeutic strategy to limit Dox-induced cardiomyopathy during cancer chemotherapy. Indeed, preliminary data show also that preventing Dox-induced cardiotoxicity, the inhibition of Epac1 can also potentiate cancerous cells death.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
ConclusionCardiac resynchronization therapy seems to be less efficient in LMNA patients compared to usual implanted patients with other type of advanced cardiomyopathy. An impaired right ventricular stroke function seems to be the only predictive factor leading to poor response to CRT.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
ConclusionThis work highlights the role of FLNCin studied cardiomyopathy subtypes. A correlation between the type of the mutation and the cardiomyopathy subtype was observed as well as with SCD risk. These new data should be taken into consideration for patient's management and primary prevention of sudden cardiac death.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Conclusion: Our work represents an important contribution to the understanding of cardiac motion, which is an important aid in the quantification of the contractility and function of the left ventricular myocardium. Significance: The intended workflow of the developed pipeline is to make use of the prior knowledge from the multimodal atlas to enable robust extraction of indicators from 3-D US images for detecting DCM patients.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
In this study, a candidate gene prioritization method was proposed for non-communicable diseases considering disease risks transferred between genes in weighted disease PPI networks with weights for nodes and edges based on functional information. Here, three types of non-communicable diseases with pathobiological similarity, Type 2 diabetes (T2D), coronary artery disease (CAD) and dilated cardiomyopathy (DCM), were used as case studies. Literature review and pathway enrichment analysis of top-ranked genes demonstrated the effectiveness of our method. Better performance was achieved after comparing our method with other ex...
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
In this study, we created a mouse model of methamphetamine cardiomyopathy that reproduces the chronic, progressive dosing commonly encountered in addicted subjects. We gradually increased the quantity of methamphetamine given to C57Bl/6 mice from 5 to 40  mg/kg over 2 or 5 months during two study periods. At the fifth month, heart weight was increased, echocardiograms showed a dilated cardiomyopathy and survival was lower in males, with less effect in females. Interestingly, these findings correspond to previous observations in human patients, sug gesting greater male susceptibility to the effects of methamphetam...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
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