Influence of Moisture Variation on the Performance of Raman Spectroscopy in Quantitative Pharmaceutical Analyses

Publication date: Available online 15 October 2018Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Md Nayeem Hossain, Benoît Igne, Carl A. Anderson, James K. DrennenAbstractTo develop a robust quantitative calibration model for spectroscopy, different sources of variability that are not directly related to the components of interest should be included in the calibration samples; this variability should be similar to that which is anticipated during validation and routine operation. Moisture content of pharmaceutical samples can vary as a function of supplier, storage conditions, geographic origin or seasonal variation. Additionally, some pharmaceutical operations (e. g., wet granulation) cause exposure of excipients and API to water. Although water is a weak Raman scatterer, moisture variability has an indirect effect on analytical model performance. Because many pharmaceutical components have intrinsic fluorescent characteristics (with broad spectral features), moisture variability may cause spectral artifacts in the form of baseline variation associated with fluorescence quenching. This work investigates the deleterious effects of water quenching on quantitative prediction accuracy of a multivariate calibration algorithm for Raman spectroscopy. To demonstrate this, a formulation composed of acetaminophen, lactose, microcrystalline cellulose, HPMC and magnesium stearate was used. Tablets were manufactured using laboratory scale equipment. A full-fact...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research

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This study aims to examine the effectiveness of the postural treatment of the Mézières method on elite rhythmic gymnastics athletes with low back pain. DESIGN: Double-blind, randomized, controlled trial. SETTING: The sports hall of "Puente Tocinos," Murcia, Spain. PARTICIPANTS: Ninety gymnastics athletes were randomized into 2 parallel groups (intervention: n = 39; control: n = 51), of whom 98.9% were women (women = 89; man = 1). INTERVENTION: The Mézières method postural therapy was implemented. It lasted about 60 minutes in repeated sessions of 2 to 3 meetings per wee...
Source: Journal of Sport Rehabilitation - Category: Sports Medicine Tags: J Sport Rehabil Source Type: research
CONCLUSIONS: Delayed activation of the VM registered in females determines an increase in anterior shear force, which is an important risk factor for incurring an ACL injury. This testing protocol becomes adequate for the screening of high-risk athletes and for targeting interventions to specific imbalances that may increase injury risk. PMID: 31711040 [PubMed - as supplied by publisher]
Source: Journal of Sport Rehabilitation - Category: Sports Medicine Tags: J Sport Rehabil Source Type: research
Authors: Fyock M, Cortes N, Hulse A, Martin J Abstract Clinical Scenario: Patellofemoral pain (PFP) is a common knee injury in recreational adult runners, possibly caused by faulty mechanics. One possible approach to reduce this pain is to retrain the runner's gait. Current research suggests that no definitive gold standard treatment for PFP exists. Gait retraining utilizing visual feedback may reduce PFP in both the short and long term. Clinical Question: In adult runners diagnosed with PFP, does gait retraining with real-time visual feedback lead to a decrease in pain? Summary of Key Findings: A literature search...
Source: Journal of Sport Rehabilitation - Category: Sports Medicine Tags: J Sport Rehabil Source Type: research
Publication date: Available online 13 November 2019Source: Materials Today CommunicationsAuthor(s): Dian Putri Hastuti, Wardah Amalia, Zakiah Priska, Pekik Nurwantoro, SholihunAbstractStabilities and atomic geometries in germanene multivacancies has been studied. We carry out eight configurations, mono-, di-, tri-, tetra-, penta-, hexa-, hepta-, and octavacancies by using the density-functional-theory calculations (DFT). We calculate formation and dissociation energies to analyze the stability by finding the magic numbers. Magic numbers are the number of vacancy belonging to stable configurations. We find that di-, tetra-,...
Source: Materials Today Communications - Category: Materials Science Source Type: research
Publication date: Available online 12 November 2019Source: Materials Today CommunicationsAuthor(s): Manorama Tripathi, Surekha Parthasarathy, Prasun Kumar RoyAbstractThis paper deals with the fabrication of non-woven polyurea nanofibers through an electrospinning process and evaluation of their mechanical properties under dynamic conditions. Polyurea is finding increasing applications for protection against dynamic loads like blast and ballistics. Processing polyurea into nanofibers can further improve their properties, especially with respect to mechanical properties and high surface areas, expanding their field of applic...
Source: Materials Today Communications - Category: Materials Science Source Type: research
Conclusion: HTX-019 administered by 2-minute injection has a tolerable safety profile in patients with cancer, representing a viable method of HTX-019 administration for CINV prevention. PMID: 31709853 [PubMed - as supplied by publisher]
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
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Source: Journal of Smooth Muscle Research - Category: Research Tags: J Smooth Muscle Res Source Type: research
Source: Autonomic Neuroscience: Basic and Clinical - Category: Neuroscience Source Type: research
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
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