Application of Pressurized Liquid Extraction (PLE) to obtain bioactive fatty acids and phenols from Laminaria ochroleuca collected in Galicia (NW Spain)

Publication date: Available online 15 October 2018Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Paz Otero, Manuel I. López-Martínez, Mónica R. García-RiscoAbstractThe increase of pathologies like cardiovascular diseases, obesity or diabetes due to the nature of diet is a matter of concern in our society. Because of this, there is a high interest in healthy natural products that could prevent the appearance of such diseases. This paper aims to study the content of fatty acids (FAs) and phenolic compounds of brown alga Laminaria ochroleuca (L. ochroleuca) and to determine the nutritional quality of the lipids extracted using pressurized liquids extraction (PLE) technique. PLE was applied to the algae using four solvents of different polarity (hexane, ethyl acetate, ethanol and ethanol:water 1:1). Results showed that the higher yield (52%), is obtained with ethanol: water solvent, however, both ethyl acetate and ethanol enrich unsaturated fatty acid (USFA) (palmitoleic, linolenic, linoleic, oleic, araquidonic and eicosapenataenoic) in the lipid fraction of L. ochroleuca, providing extracts up to 55% of their total fatty acid content compared to other solvents. The nutritional quality of the lipids in all PLE extracts was assessed by considering the ω-6/ ω-3 fatty acid ratio and two dietary indexes involved in the risks of coronary heart disease, atherogenic (AI) and thrombogenic (TI). The lower (best) index values are...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research

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CONCLUSIONS AND IMPLICATIONS FOR PUBLIC HEALTH PRACTICE: Efforts that prevent adverse childhood experiences could also potentially prevent adult chronic conditions, depression, health risk behaviors, and negative socioeconomic outcomes. States can use comprehensive public health approaches derived from the best available evidence to prevent childhood adversity before it begins. By creating the conditions for healthy communities and focusing on primary prevention, it is possible to reduce risk for adverse childhood experiences while also mitigating consequences for those already affected by these experiences. PMID: 316...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Menarche is an important event in a woman's life and is defined as the first menstrual cycle. The age at menarche (AAM) is often seen as a marker for the start of puberty in women. In previous research early menarche has shown to increase the risk of developing overweight [1] and type 2 diabetes (T2D) in adulthood [2]. In addition, both early- and late menarche has been associated with an increased risk of developing hypertension and coronary heart disease (CHD) in large UK studies [3,4].
Source: Maturitas - Category: Primary Care Authors: Source Type: research
Abstract Green tea (Camellia sinensis, Theaceace), has been extensively studied for its putative effects in prevention of age related diseases. Here, we discuss the increasing evidence that consumption of green tea has preventative effects in obesity, hypertension, insulin resistance, type II diabetes, atherosclerosis, coronary heart disease and Metabolic Syndrome (MetS). The catechins in green tea has been found to be beneficial in obesity induced by a high-fat diet. These effects are mainly attributable to the gallate esters of catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin-3- gallate (EGCG). ...
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Front Biosci (Schol Ed) Source Type: research
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Source: Journal of Behavioral Medicine - Category: Psychiatry Source Type: research
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Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research
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Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
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Authors: Jastrzebska M, Lisman D, Szelepajlo A, Oledzki S, Chelstowski K, Clark JS, Siennicka A Abstract Antiplatelet therapy resistance against acetylsalicylic acid (ASA) and/or clopidogrel in coronary heart disease (CHD) is common with diabetes mellitus. One factor might involve platelet receptor ITGB3 gene polymorphism. We aimed to assess resistance together with platelet reactivity parameters, the polymorphism, plus diabetes type 2 coexistence. The study included 185 patients with CHD, including 58 diabetics, aged 62.3 ± 8.2 years. Patients were treated long-term with ASA, plus clopidogrel, both 75 mg/d....
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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