Infantile hemangiomas with minimal or arrested growth: A retrospective case series

Pediatric Dermatology, EarlyView.
Source: Pediatric Dermatology - Category: Dermatology Authors: Source Type: research

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This study attempts to investigate the roles of linc00152 in the metastasis-related traits of infantile hemangioma (IH). Linc00152 was overexpressed in the proliferating-phase hemangioma tissues when compared with that in involuting-phase. Downregulation of linc00152 strikingly suppressed the cell viability, migration and invasion of hemangioma cells. Furthermore, silence of linc00152 repressed the growth and lung metastasis of hemangioma cell in vivo. Subsequent analysis revealed that linc00152 bound with miR-139-5p and linc00152 expression was inversely correlated with the level of miR-139-5p in IH. Same effects of miR-1...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
We report 2 cases of infants with subglottic hemangioma, in which the diagnosis was later discovered. These two infants had initially presented with stridor. They were both thoroughly investigated, but no abnormality was found after different procedures and investigations. Later, a subglottic hemangioma was seen during direct laryngobronchoscopy in the first infant. The second infant underwent multiple direct laryngobronchoscopies that were unremarkable, but the last one showed a blue rubber mass covered by normal mucosa in the subglottic area. A CT scan of the neck with contrast confirmed the diagnosis of subglottic heman...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
Abstract Hemangioma (HA) is tumor formed by hyper-proliferation of vascular endothelial cells. However, the potential effects of mono-(2-ethylhexyl) phthalate (MEHP) on the progression of HA are not well illustrated. Our present study revealed that MEHP exposure can significantly increase the in vitro proliferation of hemangioma-derived endothelial cells (HemECs). MEHP treatment can activate yes-associated protein (YAP), a key effector of Hippo pathway, by inhibiting its phosphorylation. The dephosphorylation of YAP induced by MEHP can promote the nuclear accumulation of YAP. Knockdown of YAP or its inhibitor can ...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
Oral propranolol is widely used for problematic infantile hemangiomas. Lip infantile hemangiomas present a high risk of disfigurement and associated psychosocial dysfunction requiring early treatment. Lips are compound parts that consist of the upper and the lower lips and include the mucosal and cutaneous lips histologically. This retrospective study aimed to determine the response and prognosis of different subtype of lip infantile hemangiomas to systemic propranolol.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
Publication date: September–October 2019Source: Reports of Practical Oncology &Radiotherapy, Volume 24, Issue 5Author(s): Dorota Księżniak-Baran, Sławomir Blamek, Agata Roch-Zniszczoł, Wojciech Osewski, Maja JędrzejewskaAbstractFifty-three-year-old male suffering from a presumptive non-functioning pituitary adenoma was qualified for stereotactic radiosurgery in our institution. Two attempts of surgical treatment were taken three months before radiotherapy. Excessive bleeding did not allow to remove the tumour or to take samples for histopathological examination. Diagnosis was put on the basis of radiological...
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
ConclusionsThe tubeless and uniportal video-assisted thoracoscopic surgery lung biopsy is a safe, effective, and feasible technology for definitively diagnosing patients with pulmonary capillary hemangiomatosis.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
A 73-year-old man underwent a 68Ga-PSMA-HBED-CC 11 PET/CT for evaluation of rising PSA in the context of previous radical retropubic prostatectomy and salvage radiotherapy for prostatic adenocarcinoma. There was no definite PSMA avid recurrence in the prostatic bed. Intense PSMA avid uptake was seen in the anterior aspect of the spleen. Further characterization with multiplanar multisequence pre- and post-IV contrast MRI of the upper abdomen with arterial, portal venous, and delayed phase acquisitions revealed a lesion with appearances consistent with a splenic hemangioma.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Abstract Infantile hemangiomas (IH) are the most common vascular tumor of infancy1 . Most hemangiomas follow a predictable pattern with proliferation followed by slow involution and many do not require medical or surgical intervention. However, some hemangiomas cause complications, including disfigurement, visual obstruction and/or functional impairment, which require therapeutic intervention.2 Since the discovery of beta blockers as effective topical and oral therapy for IH, hemangioma specialists suggest early therapy and referral for IH to prevent permanent sequalae3 . Yet, little is known about utilization pat...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
CONCLUSIONS: The tubeless and uniportal video-assisted thoracoscopic surgery lung biopsy is a safe, effective, and feasible technology for definitively diagnosing patients with pulmonary capillary hemangiomatosis. PMID: 31518589 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
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