Contribution of IL-1 β, 6 and TNF-α to the form of post-traumatic osteoarthritis induced by "idealized" anterior cruciate ligament reconstruction in a porcine model.

CONCLUSION: These results demonstrated that inflammatory factors are independently responsible for the onset of PTOA. PMID: 30317108 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research

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AbstractPurposeThe purpose was to calculate the incidence of osteoarthritis in individuals following Anterior Cruciate Ligament Reconstruction (ACLR) in a large, national database and to examine the risk factors associated with OA development.MethodsA commercially available insurance database was queried to identify new diagnoses of knee OA in patients with ACLR. The cumulative incidence of knee OA diagnoses in patients after ACLR was calculated and stratified by time from reconstruction. Odds ratios were calculated using logistic regression to describe factors associated with a new OA diagnosis including age, sex, BMI, me...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Introduction: Poor quality of life and early-onset post-traumatic osteoarthritis (OA) are common following anterior cruciate ligament reconstruction (ACLR), with individual outcomes varying greatly. Early identification of factors that may be related to poor patient-reported outcomes (PROs) is important, to enable targeted interventions to be developed for these individuals. Our aim was to: (i) examine how a combined injury (meniscectomy and/or significant chondral defect at time of ACLR) and early OA features on MRI influence PROs from 1 to 5 years post-ACLR and (ii) compare PROs from 1 to 5 years post-ACLR with normative...
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Authors: Tags: O89 Source Type: research
Individuals with anterior cruciate ligament reconstruction (ACLR) are at greater risk for accelerated post-traumatic knee osteoarthritis (KOA) [1]. Previous research indicates that approximately 50% of individuals with ACLR have KOA within 10 years of reconstruction surgery [1], and KOA risk is 3 times greater in the involved compared to uninvolved limb [2]. KOA is commonly assessed using imaging techniques such as magnetic resonance imaging, or radiograph [3]. However, these methods have limitations that preclude them from practical use for the purpose of identifying the progression of KOA, including lack of portability, ...
Source: Gait and Posture - Category: Orthopaedics Authors: Tags: Full length article Source Type: research
Individuals with an anterior cruciate ligament reconstruction (ACLR) demonstrate persistent alterations in walking gait characteristics even after completing traditional rehabilitation [1,2]. Evidence suggests that walking speed [3,4], alterations in kinetics and kinematics on the ACLR limb [5,6], and inter-limb asymmetries in these outcomes may contribute to poor long-term outcomes following ACLR [7,8]. Slower walking speed [3,4], less peak vertical ground reaction force (vGRF), [6] and lower vGRF loading rate [5] on the ACLR limb during walking associate with deleterious metabolic and compositional joint tissue outcomes ...
Source: Gait and Posture - Category: Orthopaedics Authors: Tags: Full length article Source Type: research
Publication date: Available online 28 March 2018 Source:Sports Orthopaedics and Traumatology Author(s): Wolf Petersen, Sven Scheffler, Julian Mehl Für die Entwicklung der posttraumatischen Gonarthrose nach VKB-Ruptur spielen primäre und sekundäre Meniskusschäden eine wichtige Rolle. Eine persistierende, chronische Instabilität nach vorderer Kreuzbandruptur kann mittel- bis langfristig zu sekundären Meniskus- und Knorpelschäden führen. Eine VKB-Plastik schützt vor sekundären Meniskusschäden. Außerdem liegt wissenschaftliche Evidenz vor, dass eine VKB-Plastik lang...
Source: Sports Orthopaedics and Traumatology - Category: Sports Medicine Source Type: research
OBJECTIVE: Anterior cruciate ligament (ACL) injury initiates a cascade of events often leading to osteoarthritis. ACL reconstruction does not alter the course of osteoarthritis, suggesting that heightened osteoarthritis risk is likely due to factors in add...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
In this study, we evaluated the form of the MM posterior segment and anterior tibial translation before and after ACL reconstruction using open magnetic resonance imaging (MRI).MethodsSeventeen patients who underwent ACL reconstructions without MM injuries were included in this study. MM deformation was evaluated using open MRI before surgery and 3  months after surgery. We measured medial meniscal length (MML), medial meniscal height (MMH), medial meniscal posterior body width (MPBW), MM–femoral condyle contact width (M-FCW) and posterior tibiofemoral distance (PTFD) at knee flexion angles of 10° and 90°...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Conclusion An accelerated return-to-sport, particularly in the presence of poor lower-limb function may be implicated in post-traumatic KOA development.
Source: PMandR - Category: Rehabilitation Source Type: research
ConclusionsComparable with other series showed in the literature, this study assesses that the use of LARS ™ in reconstruction of ACL is an excellent option for treating>40-year-old patients requesting rapid return to daily activities/sports also at the first surgery. By restoring knee stability, articular degeneration at short and medium follow-up was avoided.
Source: Musculoskeletal Surgery - Category: Orthopaedics Source Type: research
The objectives of this pilot study were to determine the safety and ...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
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