Acute Decompensated Heart Failure After Amiodarone Initiation in a Patient with Anderson-Fabry Disease

Publication date: Available online 16 October 2018Source: Canadian Journal of CardiologyAuthor(s): Nowell M. Fine, Yinong Wang, Aneal KhanAbstractA 54-year-old man with the lysosomal storage disorder Anderson-Fabry Disease (AFD) with cardiac involvement was placed on amiodarone for treatment of symptomatic paroxysmal atrial fibrillation. Shortly following he developed symptoms of acute decompensated heart failure requiring admission to hospital. Endomyocardial biopsy demonstrated findings consistent with AFD and possible amiodarone toxicity. Amiodarone was discontinued and the patient’s heart failure resolved with return to baseline status. Amiodarone is known to alter lysosomal pH and enzyme activity, and this case illustrates how it should be used with considerable caution in patients with AFD.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research