Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor

Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC05595E, CommunicationMahadeva M.M. Swamy, Yuta Murai, Yusuke Ohno, Keisuke Jojima, Akio Kihara, Susumu Mitsutake, Yasuyuki Igarashi, Jian Yu, Min Yao, Yoshiko Suga, Masaki Anetai, Kenji Monde Ginkgolic acid obtained as sphingomyelin synthase inhibitor from plant extract library inspired the concept of sphingolipid mimic. Ginkgolic acid derived N-acyl anilines and ginkgolic acid 2-phosphate (GA2P) mimics ceramide and... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Chem. Commun. latest articles - October 16, 2018 Category: Chemistry Authors: Mahadeva M.M. Swamy Source Type: research