The Fast Real-time Assessment of Combination Therapies in Immuno-ONcology (FRACTION) program: innovative, high-throughput clinical screening of immunotherapies
The unprecedented success of immuno-oncology (I-O) agents targeting the cytotoxic T lymphocyte –associated antigen 4 and programmed death-1/programmed death-ligand 1 pathways has stimulated the rapid development of other I-O agents against novel immune targets. Bristol-Myers Squibb has designed a novel phase II platform trial, the Fast Real-time Assessment of Combination Therapies in Immu no-ONcology (FRACTION) Program, to efficiently identify promising combinations for patients with specific malignancies.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Katy L. Simonsen, Paula M. Fracasso, Steven H. Bernstein, Megan Wind-Rotolo, Manish Gupta, Adriana Comprelli, Timothy P. Reilly, Jim Cassidy Tags: Original Research Source Type: research