Neuroprotective role of erythropoietin in spinal cord ischemic injury: Where have we been and where are we going?

I read with great interest the study recently published by Yamanaka and colleagues,1 reporting the results of the study aimed to pharmacologically induce β common receptor (βcR) subunit upregulation before ischemia to optimize the neuroprotective effect of erythropoietin (EPO). The authors hypothesized that βcR subunit upregulation by diazoxide (DZ) before ischemia amplifies the neuroprotective effects of EPO in mice after spinal cord injury (SCI) . They reported that that optimal βcR upregulation occurred at 36 hours after DZ administration, and the optimal DZ dosage for βcR induction was 20 mg/kg.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Adult: Aorta: Letter to the Editor Source Type: research