Assessing Copy Number Aberrations and Copy-Neutral Loss-of-Heterozygosity Across the Genome as Best Practice: An Evidence-Based Review from the Cancer Genomics Consortium (CGC) Working Group for Chronic Lymphocytic Leukemia

B-cell chronic lymphocytic leukemia (CLL), a mature B cell neoplasm, is the most common adult leukemia in the Western world. In the United States, CLL represents approximately 40% of adult leukemias, with an annual incidence of 2-6 per 100,000 and median age of diagnosis of 70 years of age. Incidence increases with age; however, 30% of patients are younger than 60 at the time of diagnosis and 15% are younger than 50 [1-3]. CLL has the highest genetic predisposition of all hematologic neoplasms; approximately 5-10% of cases have a family history of CLL or other non-Hodgkin lymphoma [4].

Source: Cancer Genetics and Cytogenetics - October 15, 2018 Category: Genetics & Stem Cells Authors: Kathy Chun, Gail D. Wenger, Alka Chaubey, D.P. Dash, Rashmi Kanagal-Shamanna, Sibel Kanturci, Ravindra Kolhe, Daniel L. Van Dyke, Lu Wang, Daynna J. Wolff, Patricia M. Miron Tags: Review Article Source Type: research