Five microRNAs in serum as potential biomarkers for prostate cancer risk assessment and therapeutic intervention

ConclusionThis study identified possible PCa tumor markers to more accurately predict the occurrence, progression, and prognosis of PCa, and which could be used in the development of tumor drug therapy.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research

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Authors: Triviño-Ibáñez EM, Puche-Sanz I, Gómez-Río M, Cózar Olmo JM, Llamas-Elvira JM, Rodríguez-Fernández A Abstract PURPOSE: To evaluate the capacity of 18f-fluorocholine positron emission tomography/computed tomography (FCH PET/CT) to detect biochemical recurrence of prostate cancer and to determine the correlation with PSA kinetics and influence of antiandrogen hormone therapy. PATIENTS AND METHODS: Observational and retrospective study, which included patients with prostate cancer and criteria for biochemical recurrence and/or resistance to castratio...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
AbstractDocetaxel pharmacokinetics are affected by androgen deprivation therapy (ADT), which is attributed to changes in liver metabolism induced by castration. In this retrospective analysis, we assessed whether initiating docetaxel treatment in close proximity to the start of ADT therapy for metastatic castrate-sensitive prostate cancer (mCSPC) is associated with more treatment-related toxicity. We identified all patients with mCSPC treated at The Ottawa Hospital that received docetaxel chemotherapy between June 2014 and September 2017. For each patient, we calculated the time to chemotherapy (TTC) interval between the s...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionS-HIFU and S-RP could both be considered valuable LST options for patients with radiation-recurrent nonmetastatic PCa with sufficient life expectancy. S-RP is associated with more pad-dependent patients at 12  months.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Prospective examination of the changes in the urinary microbiome induced by transrectal biopsy of the prostate using 16S rRNA gene analysis, Published online: 21 January 2019; doi:10.1038/s41391-018-0120-3Prospective examination of the changes in the urinary microbiome induced by transrectal biopsy of the prostate using 16S rRNA gene analysis
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Source Type: research
Exploring the risk-reward balance in focal therapy for prostate cancer—a contribution to the debateExploring the risk-reward balance in focal therapy for prostate cancer—a contribution to the debate, Published online: 21 January 2019; doi:10.1038/s41391-018-0125-yExploring the risk-reward balance in focal therapy for prostate cancer—a contribution to the debate
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Source Type: research
Performance of PCA3 and TMPRSS2:ERG urinary biomarkers in prediction of biopsy outcome in the Canary Prostate Active Surveillance Study (PASS), Published online: 21 January 2019; doi:10.1038/s41391-018-0124-zPerformance of PCA3 and TMPRSS2:ERG urinary biomarkers in prediction of biopsy outcome in the Canary Prostate Active Surveillance Study (PASS)
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Source Type: research
A lifestyle intervention of weight loss via a low-carbohydrate diet plus walking to reduce metabolic disturbances caused by androgen deprivation therapy among prostate cancer patients: carbohydrate and prostate study 1 (CAPS1) randomized controlled trialA lifestyle intervention of weight loss via a low-carbohydrate diet plus walking to reduce metabolic disturbances caused by androgen deprivation therapy among prostate cancer patients: carbohydrate and prostate study 1 (CAPS1) randomized controlled trial, Published online: 21 January 2019; doi:10.1038/s41391-019-0126-5A lifestyle intervention of weight loss via a ...
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Source Type: research
Publication date: Available online 18 January 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Polly Zhang, Adam Schatz, Babatunde Adeyemi, David Kozminski, JoEllen Welsh, Martin Tenniswood, Wei-Lin Winnie WangAbstractVitamin D3 and its receptor are responsible for controlling energy expenditure in adipocytes and have direct roles in the transcriptional regulation of energy metabolic pathways. This phenomenon also has a significant impact on the etiology of prostate cancer (PCa). Using several in vitro models, the roles of vitamin D3 on energy metabolism and its implication in primary, early ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 18 January 2019Source: European UrologyAuthor(s): Axel Semjonow, Hans-Werner Hense, Kathrin Schlößler, Alexandra Simbrich, Matthias Borowski, Christiane Bothe, Klaus Kruse, Dorothee Tiedje, Kathrin Kuss, Charles Christian Adarkwah, Peter Maisel, Ralf Jendyk, Marc-André Kurosinski, Joachim Gerß, Oliver Heidinger, Christian Tschuschke, Ralf Becker, Monique J. Roobol, Chris Bangma, Norbert Donner-Banzhoff
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 18 January 2019Source: European UrologyAuthor(s): Niranjan J. Sathianathen, Badrinath R. Konety
Source: European Urology - Category: Urology & Nephrology Source Type: research
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