The lifespan Human Connectome Project in aging: An overview

Publication date: Available online 15 October 2018Source: NeuroImageAuthor(s): Susan Y. Bookheimer, David H. Salat, Melissa Terpstra, Beau M. Ances, Deanna M. Barch, Randy L. Buckner, Gregory C. Burgess, Sandra W. Curtiss, Mirella Diaz-Santos, Jennifer Stine Elam, Bruce Fischl, Douglas N. Greve, Hannah A. Hagy, Michael P. Harms, Olivia M. Hatch, Trey Hedden, Cynthia Hodge, Kevin C. Japardi, Taylor P. Kuhn, Timothy K. LyAbstractThe original Human Connectome Project yielded a rich data set on structural and functional connectivity in a large sample of healthy young adults using improved methods of data acquisition, analysis, and sharing. More recent efforts are extending this approach to include infants, children, older adults, and brain disorders. This paper introduces and describes the Human Connectome Project in Aging (HCP-A), which is currently recruiting 1200 + healthy adults aged 36 to 100+, with a subset of 600 + participants returning for longitudinal assessment. Four acquisition sites using matched Siemens Prisma 3T MRI scanners with centralized quality control and data analysis are enrolling participants. Data are acquired across multimodal imaging and behavioral domains with a focus on factors known to be altered in advanced aging. MRI acquisitions include structural (whole brain and high resolution hippocampal) plus multiband resting state functional (rfMRI), task fMRI (tfMRI), diffusion MRI (dMRI), and arterial spin labeling (ASL). Behavioral characterization i...
Source: NeuroImage - Category: Neuroscience Source Type: research