Many cases of dementia may arise from non-inherited DNA 'spelling mistakes'

(University of Cambridge) Only a small proportion of cases of dementia are thought to be inherited -- the cause of the vast majority is unknown. Now, in a study published today in the journal Nature Communications, a team of scientists led by researchers at the University of Cambridge believe they may have found an explanation: spontaneous errors in our DNA that arise as cells divide and reproduce.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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ConclusionsThe educational intervention was designed to increase awareness and understanding of the nursing staff regarding the nature, characteristics, negative outcomes, and costs of delirium, as well as the success and net monetary benefit of prevention protocols. The educational program focused on practical strategies derived from the NICE Clinical Guideline 103. Delirium prevention reduces length of stay, healthcare costs, and nursing hours per patient day. Prevention also improves patient outcomes. The minimal costs of the protocol will increase nursing and administrative support for prevention interventions.Nurses a...
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Publication date: Available online 10 November 2018Source: Social Science &MedicineAuthor(s): Jennifer A. Smith, Minjung Kho, Wei Zhao, Miao Yu, Colter Mitchell, Jessica D. FaulAbstractBoth social and genetic factors contribute to cognitive impairment and decline, yet genetic factors identified through genome-wide association studies (GWAS) explain only a small portion of trait variability. This “missing heritability” may be due to rare, potentially functional, genetic variants not assessed by GWAS, as well as gene-by-social factor interactions not explicitly modeled. Gene-by-social factor interactions may ...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
DiscussionThe forms of tau in CSF and plasma are distinct, but in each specimen type, the levels of certain fragments are increased in AD. Measurement of plasma NT1 tau should be aggressively pursued as a potential blood-based screening test for AD/AD-MCI.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: Available online 10 November 2018Source: Food Research InternationalAuthor(s): Diana Denise Dohrmann, Predrag Putnik, Danijela Bursać Kovačević, Jesus Simal-Gandara, Jose M. Lorenzo, Francisco J. BarbaAbstractEnvironmental factors are responsible of cellular senescence and processes found in the development of cognitive disorders. The aim of this paper is to compare benefits of the Japanese, Mediterranean, and Argentinian Diet on the onset or prevention of senile dementia (SD) and Alzheimer's Disease (AD). Special focus was on the effects of specific compounds such as polyunsaturated fatty acids (PUFAs...
Source: Food Research International - Category: Food Science Source Type: research
The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer’s Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.  Click arrow to play Download TWiV 519 (58 MB .mp3, 96 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology acyclovir alzheimer's disease amyloid plaque antiviral beta amyloid herpes simplex virus HSV-1 senile dementia viruses Source Type: blogs
In conclusion, our data support that weight loss negatively confounds the association between late-life obesity and brain atrophy. The obesity paradox on AD risk might be explained by reverse causation. PMID: 30410669 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Gavurová B, Kováč V, Jarčušková D Abstract Alzheimer's disease-subsequently as AD in the text-represents a chronic neurodegenerative disease discussed very often in the recent period. It involves the G30 diagnosis expressing exactly AD and also the F00 diagnosis epitomising dementia in AD. The Slovak Republic has a very various population in terms of the disparities of the population localisation. The analysis is executed on the basement of the standardised mortality rate. It is calculated for the individual districts of the Slovak Republic to get a detailed spatial view and f...
Source: International Journal of Alzheimers Disease - Category: Geriatrics Tags: Int J Alzheimers Dis Source Type: research
Dementia risk can be reduced 40% in this common way. → Enjoying these psych studies? Support PsyBlog for just $4 per month (includes ad-free experience and more articles). → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: NEW: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Loneliness Source Type: blogs
This study finds such transitions are not consistent with goals of providing dying patients with comfort.By Alzheimer's Reading RoomA study in theNew England Journal of Medicine reports thatnearly one in five nursing home residents with advanced dementia experiences burdensome transitions in the last 90 days of life.This includes moving to a different facility in the last three days of life or repeat hospitalizations for expected complications of dementia in the last 90 days of life."Ultimately, all of these problems are signs of care gone awry.The best care for a patient with advanced cognitive impairment near the en...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: aging alzheimers care alzheimers information dementia elder care health medical science nursing home palliative care Source Type: blogs
In this study, we developed a novel model for chronic irreversible cerebral hypoperfusion in mice. Briefly, an ameroid constrictor was placed on the right carotid artery to gradually occlude the vessel, while a microcoil was placed on the left carotid artery to prevent compensation of the blood flow. This procedure resulted in a gradual hypoperfusion developing over a period of 34  days with no cerebral blood flow recovery. Histological analysis of the brain revealed neuronal and axonal degeneration as well as necrotic lesions. The most severely affected regions were located in the hippocampus and the corpus callosum....
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
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