Gold-Nanobranched-Shell based drug vehicles with ultrahigh Photothermal efficiency for chemo-Photothermal therapy

Publication date: Available online 14 October 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Yanping Liu, Xuwu Zhang, Liyao Luo, Lei Li, Rui Yan Zhu, Anshuo Li, Yuchu He, Weiwei Cao, Kang Niu, Huan Liu, Jingyue Yang, Dawei GaoAbstractDevelopment of combined chemo-photothermal nanoplatform is of great interest for enhancing antitumor efficacy. Herein, a multifunctional drug delivery system was synthesized based on gold-nanobranched coated betulinic acid liposomes (GNBS-BA-Lips) for chemo-photothermal synergistic therapy. In this system, GNBS-BA-Lips exhibited broad near-infrared (NIR) absorption, preferable photothermal response and good photostability under NIR irradiation. Importantly, the gold-nanobranched nanostructure possessed high photothermal conversion efficiency (η = 55.7%), and the temperature change (ΔT) reached 43.2 °C after laser irradiation for 5 min. Upon NIR irradiation, the nanocarriers apparently endowed higher cell uptake, resulting in an enhanced intracellular drug accumulation. Furthermore, the tumor growth inhibition ratio achieved from chemo-photothermal therapy of GNBS-BA-Lips was 86.9 ± 1.1%, which was higher than that of the chemotherapy or photothermal therapy alone, showing an outstanding synergistic anticancer effect. Our data suggested that the nanoplatform should be considered as a critical platform in the development of cancer multi-mode therapies.Graphical AbstractA natural compound, ...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research