Managing complications of hypertension in aortic valve stenosis patients.

Managing complications of hypertension in aortic valve stenosis patients. Expert Rev Cardiovasc Ther. 2018 Oct 12;: Authors: Saeed S, Gerdts E Abstract INTRODUCTION: Hypertension is highly prevalent in aortic stenosis (AS) patients as the prevalence of both disorders increases with age. Hypertension and associated stiffening of the large arteries increase afterload and thereby influence both the transvalvular flow and the remodelling of the aortic root and the left ventricle during AS progression. Area covered: The present review gives an overview on complications of hypertension in AS, how these can be diagnosed, and potentially may be managed. Expert commentary: Hypertension-mediated cardiovascular damage in AS is associated with increased morbidity and a 2-fold higher mortality even in asymptomatic patients, and also limits the symptomatic and survival benefit from valve replacement. Data from registries and post-hoc analyses from outcome studies in AS suggest that treatment with angiotensin converting enzyme inhibitors, angiotensin receptor blockers and β-blockers, respectively, is safe and associated with improved survival and reduced cardiovascular events in these patients. However, optimal blood pressure target in AS patients is not documented, and strict blood pressure control in the early post-operative phase in AS patients treated with transcatheter aortic valve replacement (TAVR) may be associated with adverse events. Thu...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research