Loss of EfnB1 in the osteogenic lineage compromises their capacity to support haematopoietic stem/ progenitor cell maintenance

The haematopoietic stem/ progenitor cell (HSPC) niche is composed of diverse cellular components that contribute to HSPC maintenance and niche function within the bone marrow. These include arterioles, sinusoidal endothelial cells, Nestin+ mesenchymal stem cells, stromal populations including bone marrow stromal stem cells (BMSC)/ perivascular reticular cells and cells of the osteogenic lineage [1 –9]. These cells are key mediators of HSC maintenance, proliferation, differentiation and maturation, acting in a non-cell-autonomous manner through membrane dependent or soluble chemokines and growth factors.

Source: Experimental Hematology - October 13, 2018 Category: Hematology Authors: Agnieszka Arthur, Thao M. Nguyen, Sharon Paton, Andrew C.W. Zannettino, Stan Gronthos Source Type: research